Results 41 to 50 of about 1,709,689 (401)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Upper and lower plane bed definitions revised

open access: yesProgress in Earth and Planetary Science, 2022
Sedimentary structures in ancient deposits are clues to reconstruct past geohazards. While parallel lamination formed by plane beds is one of the most common sedimentary structures in event deposits such as turbidites, the formative conditions for plane ...
Koji Ohata   +2 more
doaj   +1 more source

Eelgrass Distribution in the Great Bay Estuary 2007 [PDF]

open access: yes, 2008
Eelgrass has now, in 2007, almost totally disappeared from Little Bay and the Piscataqua River. Despite these critical losses in mid-estuary, eelgrass distribution in the Great Bay Estuary (GBE) as a whole between 2006 and 2007 experienced an overall ...
Short, Frederick T.
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Flow Studies using Laser Anemometry Technique in a Small Power Unit Radial Inflow Turbine

open access: yesInternational Journal of Rotating Machinery, 1997
T-100 is a multipurpose small power unit developed by Sundstrand Power Systems (USA). An extensive research programme was launched for the detailed tests of the rig components including inlet protection system, Compressor stage, Combustor and the Turbine
Sohail H. Zaidi, Robin L. Elder
doaj   +1 more source

Does the Use of Perennials in Flower Beds Necessarily Imply Sustainability?

open access: yesPlants, 2023
Green spaces are becoming increasingly important for cities due to the growing pressures of urbanization and climate change. Along with trees, shrubs, and lawns, flower beds are an important part of urban green spaces.
Miroslav Poje   +3 more
doaj   +1 more source

Design method for adsorption beds [PDF]

open access: yes, 1970
Regenerable adsorption beds for long-term life support systems include synthetic geolite to remove carbon dioxide and silica gel to dehumidify the atmospheric gas prior to its passage through the geolite beds. Bed performance is evaluated from adsorption
Blakely, R. L., Jackson, J. K.
core   +1 more source

Optimization of Powder Layer Density in Selective Laser Sintering [PDF]

open access: yes, 1999
An important parameter for the overall quality of SLS parts is the density of powder layers before sintering. Previous studies have shownthatthe control of powder particle shape and size distribution can increase the density of non-packed powder beds ...
Egger, G.   +3 more
core   +1 more source

Estimation of the bed shear stress in vegetated and bare channels with smooth beds

open access: yes, 2015
The shear stress at the bed of a channel influences important benthic processes such as sediment transport. Several methods exist to estimate the bed shear stress in bare channels without vegetation, but most of these are not appropriate for vegetated ...
Judy Q. Yang, F. Kerger, H. Nepf
semanticscholar   +1 more source

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