Results 101 to 110 of about 156,693 (286)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, EarlyView.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats [PDF]

Addiction and Health, 2014
Background: Consumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments.
Shima Torkzadeh-Mahani, Sima Nasri, Saeed Esmaeili-Mahani   +2 more
doaj  

Addictive behavior in cinema demand: evidence from Korea [PDF]

It is intuitively plausible that the demand for cinema services may be partly driven by addiction or habit. Yet there is almost no empirical literature which tests for whether cinema demand is addictive.
Donghyun PARK, Sangho KIM
core  

Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAa receptor B3 subunit genes [PDF]

, 2004
Molecular genetic research has identified promising markers of alcohol dependence, including alleles of the D2 dopamine receptor (DRD2) and the GABAA receptor ￢3 subunit (GABRB3) genes.
Bandura, Bandura, Bau, Berman, Berridge, Blomqvist, Blum, Bruce R Lawford, Christiansen, Cohen, Comings, Connor, Connor, David, Davies, Depue, DiChiara, DiChiara, DiChiara, DiChiara, Dimitrov, Duan, Dudek, Ernest P Noble, Feeney, Gelernter, Gerald F.X Feeney, Goldman, Grandy, Greenfield, Gurling, Hitzemann, Hollerman, Ikemoto, Jönsson, Kidd, Knight, Laruelle, Lawford, Lawford, Lawford, Lawford, Long, Luddens, Madrid, Maldonado, McCarthy, McCarthy, Miller, Monti, Mutirangura, Neiswanger, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noone, Ott, Pato, Persico, Pohjalainen, Robinson, Ross McD Young, Schultz, Schultz, Selzer, Silvestri, Spitz, Terry Ritchie, Thanos, Thompson, Uhl, Vernon, Vik, Volkow, Volkow, Wells-Parker, Williams, Wilson, Wise, Young, Young, Young, Young   +87 more
core   +2 more sources

Thirty Years of Mentoring by “Bob Chan” of Young Japanese Surgeons to Become Scientists: An Adventure of Love

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Over the past three decades, we have mentored a generation of young Japanese surgeons, guiding them to become internationally recognized surgeon‐scientists. Through a unique collaboration between Japanese academic institutions and our laboratories at AntiCancer Inc.
Robert M. Hoffman, Kentaro Miyake, Itaru Endo   +2 more
wiley   +1 more source

Optimal inference with suboptimal models:Addiction and active Bayesian inference [PDF]

, 2014
When casting behaviour as active (Bayesian) inference, optimal inference is defined with respect to an agent's beliefs - based on its generative model of the world.
Adams, Adams, Bechara, Beck, Beck, Belin, Berke, Berridge, Berridge, Bickel, Bishop, Blum, Blum, Blum, Bowers, Bowers, Brighton, Cain, Charness, Christoph Mathys, Clark, Clark, Comings, Conant, Daunizeau, Daw, Dayan, Dayan, Diana, Dolan, Doyon, Edwards, Everitt, Everitt, Eysenck, FitzGerald, Friedrich Wurst, Friston, Friston, Friston, Friston, Friston, Friston, Geisler, Gigerenzer, Gillan, Graybiel, Grether, Griffiths, Griffiths, Henden, Hommer, Jones, Kahnemann, Karl Friston, Kersten, Knill, Lee, MacKay, Mahmood, Maia, Martin Kronbichler, Miedl, Montague, Monterosso, Pellicano, Peters, Peters, Philipp Schwartenbeck, Pouget, Ray Dolan, Redish, Redish, Robinson, Schwartenbeck, Simon, Simon, Stephan, Story, Sutton, Taber, Tenenbaum, Thomas H.B. FitzGerald, Tversky, Tversky, Weiss, Whalley, Willuhn, Wolpert, Yu   +89 more
core   +2 more sources

Giving and receiving help in three contexts as predictors of alcohol outcomes in a longitudinal study of sober living house residents

American Journal of Community Psychology, EarlyView.
Abstract Although peer support is central to the social model approach emphasized in sober living houses (SLHs), no longitudinal studies have examined helping among SLH residents. This longitudinal study examined benefits of helping in three contexts among SLH residents. Data were from 205 participants entering 28 SLHs across 2021–2023. Interviews were
Sarah E. Zemore, Elizabeth Mahoney, Meenakshi S. Subbaraman, Amy A. Mericle, Douglas L. Polcin   +4 more
wiley   +1 more source

Correction: G-CuP: the effect of a forced oral glucose intake on alcohol craving and mesolimbic cue reactivity in alcohol dependence—study protocol of a randomized, double-blind, placebo-controlled crossover study

Trials, 2022
Lea Wetzel, Madeleine Pourbaix, Alisa Riegler, Anna-Maria Pfeifer, Iris Reinhard, Sabine Hofmann, Sabine Vollstädt-Klein, Falk Kiefer, Wolfgang Sommer, Jan Malte Bumb, Patrick Bach, Anne Koopmann   +11 more
doaj   +1 more source

Fortune telling addiction: Unfortunately a serious topic about a case report [PDF]

, 2015
Background: Constant social change brings about new forms of behavior, such as smartphone use, social network-ing, indoor tanning, cosmetic surgery, etc., that could become excessive or even lead to new forms of addictive disor-ders.
Bouju, Gaëlle, Bulteau, Samuel, Grall-Bronnec, Marie, Sauvaget, Anne, Victorri-Vigneau, Caroline   +4 more
core   +3 more sources