Results 71 to 80 of about 297,345 (313)
Kaohsiung Journal of Medical Sciences, 2012 Hyperactivation of glutamatergic N-methyl-D-aspartate (NMDA) receptors has been implicated in the excitotoxicity and pathophysiology of Parkinson's disease (PD).
Cornelius Rainer Pawlak +3 more
doaj +1 more source
Gaming addiction, definition, and measurement: a large-scale empirical study [PDF]
, 2013 Aims: Although the general public appears to have embraced the term 'video game addiction', the scientific debate as to whether 'gaming addiction' can actually be considered an addiction similar to substance addictions of DSM-IV is still unsettled. To
Griffiths, MD +3 more
core +1 more source
Advanced Science, EarlyView.Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai +12 more
wiley +1 more source
Advanced Science, EarlyView.SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui +15 more
wiley +1 more source
Association between smartphone overdependence and mental health in South Korean adolescents: a secondary data analysis [PDF]
Child Health Nursing ResearchPurpose The rising prevalence of smartphone overdependence among adolescents and its detrimental impact on mental health have become a growing concern.
Hyeseon Yun, Eun Kyoung Choi
doaj +1 more source
Frontiers in Psychiatry, 2022 IntroductionConducted under the auspices of the Italian Society of Consultation Liaison Psychiatry (SIPC) the aim of this study was to describe the characteristics of Consultation Liaison Psychiatry (CLP) activity in Italy (SIPC-2—2018) over the past 20 ...
Luigi Zerbinati +45 more
doaj +1 more source
Behavioral addictions in addiction medicine [PDF]
, 2016 Recent progress has been made in our understanding of nonsubstance or "behavioral" addictions, although these conditions and their most appropriate classification remain debated and the knowledge basis for understanding the pathophysiology of and treatments for these conditions includes important gaps.
Marc N. Potenza +3 more
openaire +3 more sources
Факторна структура опановуючої поведінки осіб з різним рівнем адиктивної ідентичності [PDF]
, 2015 Shylina, A.A. and Gresa, N.V. (2015), “Factor structure of coping behavior of individuals with different levels of addictive identity” [“Faktorna struktura opanovuiuchoi povedinky osib z riznym rivnem adyktyvnoi identychnosti”], Pravo i Bezpeka, No. 2,
Gresa, N. V. +3 more
core
FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity
Advanced Science, EarlyView.Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li +11 more
wiley +1 more source
Clinical Psychology &Psychotherapy, Volume 29, Issue 6, Page 1942-1949, November/December 2022., 2022 Abstract Supervision seems to be an essential part of therapist training and thus also of implementing evidence‐based practices. However, there is a shortage of valid and reliable instruments for objective assessment of supervision competence that include both global measures and frequency counts of behaviour—two essential aspects of supervisory ...
Maria Beckman +4 more
wiley +1 more source