Results 121 to 130 of about 10,938,470 (249)

Visible Pregnancy, Invisible HIV: How Social Norms Shape Adolescents Protection Choice in Kenya and Nigeria

Annals of Global Health
Adolescents in sub‑Saharan Africa continue to face a high burden of HIV, with adolescent girls and young women disproportionately affected. Yet despite major investments in HIV education, testing, condoms, and biomedical prevention such as PrEP ...
Cassange Bitère, Raphael Joshua Ifenna, Hilawit Gebrehanna, Dorcas Nyasani Ombasa   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mpox Awareness, Risk Reduction, and Vaccine Acceptance among People with HIV in Washington, DC

Pathogens
People with HIV (PWH) are disproportionally affected by mpox and at risk of severe complications. We assessed mpox knowledge, adoption of preventive behaviors, and vaccination attitudes among PWH enrolled in a longitudinal HIV cohort in Washington, DC ...
Elisabeth W. Andersen, Paige Kulie, Amanda D. Castel, Jose Lucar, Debra Benator, Alan E. Greenberg, Anne Monroe   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synthesis and Assessment Products

, 2008
This report summary outlines brief answers to four questions about climate change. Will there be an abrupt change in sea level? Will there be an abrupt change in the hydrologic cycle?
National Science and Technology Council (U.S.). Subcommittee on Global Change Research., Climate Change Science Program (U.S.)   +1 more
core  

Fungal Pathogen Infection by Metarhizium anisopliae Alters Climbing Behavior of Lymantria dispar with Tree-Top Disease Induced by LdMNPV

Biology
Certain parasites manipulate host behavior following infection to enhance their own dispersal and transmission. Lepidopteran larvae infected with baculoviruses exhibit increased locomotion, ascending to the apex of their host plant where they ultimately ...
Qi Song, Yu-Shan Wei, Dun Wang
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A model for pre-service teachers' climate change awareness and willingness to act for pro-climate change friendly behavior: adaptation of awareness to climate change questionnaire

, 2015
Public awareness of the negative effects of climate change is vital since it leads to collective action for prevention and adaptation. However, investigations on to what extent people are aware of the climate change issue are rare in the literature.
Alper, Umut, Ozdem-Yilmaz, Yasemin, Dal, Burçkin, Ozturk, Nilay, SÖNMEZ, DUYGU   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source