Results 91 to 100 of about 2,827,572 (302)

Trastorno depresivo persistente: Evaluación clínica y abordaje psicoterapéutico desde la terapia cognitivo conductual. Estudio de caso único

Clínica Contemporánea
El trastorno depresivo persistente (TDP) afecta el estado de ánimo, suele tener una aparición temprana en el desarrollo, y estar presente durante al menos dos años.
Johanna Sibaja-Molina
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

PRO*MDD Study Protocol: Effectiveness of Outpatient Treatment Programs for Major Depressive Disorder: Metacognitive Therapy vs. Behavioral Activation a Single-Center Randomized Clinical Trial

Frontiers in Psychiatry, 2018
Background: Major depressive Disorder (MDD) is a severe mental disorder associated with considerable disability and high costs. Over the last decades, various psychotherapies for MDD have been developed and researched, among others Behavioral Activation (
Anja Schaich, Laura Heikaus, Nele Assmann, Sandra Köhne, Kamila Jauch-Chara, Michael Hüppe, Adrian Wells, Adrian Wells, Ulrich Schweiger, Jan Philipp Klein, Eva Fassbinder   +10 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Mechanisms of Change in Behavioral Activation: Adapting Depression Treatment for Autistic People

, 2023
Despite high rates of co-occurring depression, few studies have developed or adapted treatments targeting depressive symptoms for autistic adults. Behavioral activation is widely accepted as an empirically-supported approach for treating depression in ...
Wilkinson, Ellen, Richard P. Hastings, Glascock, Victoria, Jahoda, Andrew, Bal, Vanessa H, Bal, Vanessa H., Andrew Jahoda, Hastings, Richard P, Hastings, Richard P., Hastings, Richard P.; id_orcid, Vanessa H. Bal, Victoria Glascock, Ellen Wilkinson   +12 more
core   +1 more source

Psychological rehabilitation: cognitive behavioral therapy

Реабилитология
Cognitive behavioral therapy (CBT) is considered to be a highly effective and evidence-based psychotherapeutic method aimed at modifying irrational thoughts and dysfunctional behaviors.
T. A. Solokhina, E. M. Lyadnova
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Pilot trial results of D-HOMES: a behavioral-activation based intervention for diabetes medication adherence and psychological wellness among people who have been homeless

Frontiers in Psychiatry
IntroductionPeople living with type 2 diabetes who experience homelessness face a myriad of barriers to engaging in diabetes self-care behaviors that lead to premature complications and death. This is exacerbated by high rates of comorbid mental illness,
Katherine Diaz Vickery, Katherine Diaz Vickery, Katherine Diaz Vickery, Katherine Diaz Vickery, Lillian Gelberg, Lillian Gelberg, Audrey Rose Hyson, Audrey Rose Hyson, Ella Strother, Ella Strother, Jill Carter, Oscar Oranday Perez, Moncies Franco, Moncies Franco, Silvio Kavistan, Silvio Kavistan, Susan Gust, Edward Adair, Ali’Cia Anderson-Campbell, Lelis Brito, Annette Butler, Tahiti Robinson, John Connett, Michael D. Evans, Karen M. Emmons, W. Scott Comulada, W. Scott Comulada, Andrew M. Busch, Andrew M. Busch, Andrew M. Busch   +29 more
doaj   +1 more source