Results 121 to 130 of about 2,827,572 (302)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Activation and Avoidance Mediate the Relationship Between Depression and Life Satisfaction: Insights from Behavioral Activation Therapy

Behavioral activation therapy has been increasingly used in depression intervention in recent years. It aims to increase the activation level and decrease the avoidance level.
Kosan, Yavuz, Kaya, M. Siyabend
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Behavioral activation for depression in groups embedded in psychosomatic rehabilitation inpatient treatment: a quasi-randomized controlled study

Frontiers in Psychiatry
BackgroundBehavioral activation (BA) and cognitive-behavioral therapy (CBT) have shown to be efficacious treatment methods for depression. Previous studies focused mostly on the outpatient treatment either in group or individual setting.
Ursula Melicherova, Tobias Schott, Volker Köllner, Volker Köllner, Jürgen Hoyer   +4 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Enduring effects of a five-week behavioral activation program for subthreshold depression among late adolescents: an exploratory randomized controlled trial

, 2018
Koki Takagaki,1 Yasumasa Okamoto,2 Ran Jinnin,2 Asako Mori,2 Yoshiko Nishiyama,3 Takanao Yamamura,4 Satoshi Yokoyama,2 Syouichi Shiota,5,6 Yuri Okamoto,1 Yoshie Miyake,1 Akiko Ogata,7 Yoshihiko Kunisato,8 Haruki Shimoda,9 Norito Kawakami,10 Toshi A ...
Kunisato Y, Yokoyama S, Takagaki K, Ogata A, Mori A, Furukawa TA, Jinnin R, Okamoto Y, Shiota S, Nishiyama Y, Shimoda H, Miyake Y, Kawakami N, Yamawaki S, Yamamura T   +14 more
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Behavioral Activation for Treatment-resistant Depression: Theoretical Model and Intervention Protocol (BA-TRD)

Clínica y Salud. Investigación Empírica en Psicología
Background: Treatment-resistant depression (TRD) is a severe public health problem and a condition uncommonly addressed by psychological therapies.
Michel A. Reyes-Ortega, Jorge Barraca, Jessica Zapata-Téllez, Alejandra M. Castellanos-Espinosa, Joanna Jiménez-Pavón   +4 more
doaj   +1 more source

Behavior of Active Polymer Knots

Macromolecules
We investigate active polymer knots using Brownian dynamics simulations. We find the interplay of active force, chain connectivity, and knotting leads to several unexpected phenomena. First, active force significantly tightens knots through activity-induced stretching effect. The magnitude of the stretching effect differs greatly in and out of the knot
Zhiyu Zhang, Longfei Li, Yongjian Zhu, Rui Zhang, Mingcheng Yang, Liang Dai   +5 more
openaire   +2 more sources