Results 121 to 130 of about 294,548 (281)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Frequency-specific segregation and integration of human cerebral cortex: An intrinsic functional atlas

iScience
Summary: The cognitive and behavioral functions of the human brain are supported by its frequency multiplexing mechanism. However, there is limited understanding of the dynamics of the functional network topology.
Zhiguo Luo, Erwei Yin, Ling-Li Zeng, Hui Shen, Jianpo Su, Limin Peng, Ye Yan, Dewen Hu   +7 more
doaj   +1 more source

Preparation and use of wireless reprogrammable multilateral optogenetic devices for behavioral neuroscience. [PDF]

Nat Protoc, 2022
Yang Y, Wu M, Wegener AJ, Vázquez-Guardado A, Efimov AI, Lie F, Wang T, Ma Y, Banks A, Li Z, Xie Z, Huang Y, Good CH, Kozorovitskiy Y, Rogers JA.   +14 more
europepmc   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Structured evaluation of rodent behavioral tests used in drug discovery research

, 2014
A large variety of rodent behavioral tests are currently being used to evaluate traits such as sensory-motor function, social interactions, anxiety-like and depressive-like behavior, substance dependence and various forms of cognitive function.
Marklund, Niklas, Hånell, Anders, Hånell, Anders,, Marklund, Niklas,, Anders HÃ¥nell, Niklas Marklund   +5 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Hemispheric asymmetry in depressive symptoms is associated with sex-divergent functional brain connectivity patterns

iScience
Summary: Hemispheric asymmetry has been linked to depressive symptoms, yet its relationship with large-scale brain network organization remains unclear.
Shuqi Jia, Weizhi Liu, Qun Zhao, Somang Yun, Xin Xin, Cong Liu, Shufan Li, Peng Wang, Zhaosong Yin, Wei Guan, Fen Yu, Qing Liu, Zhaohui Guo, Xi Wang, Xing Wang   +14 more
doaj   +1 more source

Advancements in Genomic and Behavioral Neuroscience Analysis for the Study of Normal and Pathological Brain Function. [PDF]

Front Mol Neurosci, 2022
Baratta AM, Brandner AJ, Plasil SL, Rice RC, Farris SP.   +4 more
europepmc   +1 more source

Introduction to Behavioral Neuroscience

913 p.Introduction to Behavioral Neuroscience aligns to the topics and objectives of introductory behavioral neuroscience courses taught in psychology, biology, neuroscience, and similar departments.
Kirby, Elizabeth D., Williams, Christina L., Sandstrom, Noah J., Glenn, Melissa J.   +3 more
core  

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source