Results 31 to 40 of about 263,500 (249)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Dual roles of Drosophila reward-encoding dopamine neurons in regulating innate and learned behaviors

iScience
Summary: Dopaminergic neurons (DANs) play a key role in learning the value of cues that predict reward. The fruit fly Drosophila has provided a powerful model to dissect the mechanisms by which reward-encoding DANs mediate reward learning.
Fiorella V. Lozada-Perdomo, Yuzhen Chen, Ruby V. Jacobs, Joyce Yeo, Meifeng (Maia) Yang, Janhavi Bhalerao, Anita V. Devineni   +6 more
doaj   +1 more source

TMS-induced inhibition of the left premotor cortex modulates illusory social perception

iScience, 2023
Summary: Communicative actions from one person are used to predict another person’s response. However, in some cases, these predictions can outweigh the processing of sensory information and lead to illusory social perception such as seeing two people ...
Charline Peylo, Elisabeth F. Sterner, Yifan Zeng, Elisabeth V.C. Friedrich, Annika Bingger, Gabriel Engelhardt, Viola Gnam, Marie Gottmann, Christof Leininger, Zdislava Lukasova, Keno Mersmann, Ada Özbey, Liisbeth Pirn, Jacob Riecke, Sarah Schellnast, Gina Marie Schowe, Dominik Weidenhöfer, Jasmin Wunderatzke, Nele Wunner   +18 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Tracking spatial patterns and daily modulation of behavior in a natural population of the pulse-type weakly electric fish, Gymnotus omarorum

iScience
Summary: Tracking individual spatial and activity-rest patterns in natural populations is challenging because it is seldom possible to monitor individual-specific traits continuously.
Adriana Migliaro, Federico Pedraja, Stefan Mucha, Jan Benda, Ana Silva   +4 more
doaj   +1 more source

Transfer from Number to Size Reveals Abstract Coding of Magnitude in Honeybees

iScience, 2020
Summary: Number discrimination has been documented in honeybees. It is not known, however, whether it reflects, as in vertebrates, the operating of an underlying general magnitude system that estimates quantities irrespective of dimensions (e.g., number,
Maria Bortot, Gionata Stancher, Giorgio Vallortigara   +2 more
doaj   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Organizational Neuroscience of Industrial Adaptive Behavior [PDF]

, 2022
Stephen Fox, Adrian Kotelba
openalex   +1 more source

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster, Jae Woo Chung, Maria E. Linn‐Evans, Matthew N. Petrucci, Chiahao Lu, Destiny J. Weaver, Joshua De Kam, Scott E. Cooper, Paul J. Tuite, Aleksandar Videnovic, Michael J. Howell, Colum D. MacKinnon   +11 more
wiley   +1 more source