Results 51 to 60 of about 295,516 (281)

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Gaboxadol normalizes behavioral abnormalities in a mouse model of fragile x syndrome [PDF]

, 2022
Art. 141, 9 S.Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep, repetitive behaviors, and self-injury.
During, M.J., Warner-Schmidt, J.L., Deacon, R.M.J., Abrahams, B.S., Cogram, P., Schimmelmann, M.J. von   +5 more
core   +1 more source

Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex

iScience
Summary: Positive emotions determine individual well-being and sustainable social relationships. Here, we examined the neural processes mediating upregulation of positive social emotions using functional magnetic resonance imaging in healthy female ...
Dmitriy D. Bezmaternykh, Mikhail Ye. Melnikov, Evgeny D. Petrovskiy, Ksenia G. Mazhirina, Andrey A. Savelov, Mark B. Shtark, Patrik Vuilleumier, Yury Koush   +7 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Editorial: Focus feature on biomarkers in network neuroscience [PDF]

, 2022
There is an ongoing need for novel biomarkers in clinical neuroscience, as diagnosis of neurological and psychiatric disorders is hampered by the pronounced overlap of behavioral symptoms and other pathophysiological characteristics.
Senden, Mario, van den Heuvel, Martijn, Heuvel, Martijn van den, Senden, Mario; id_orcid, Douw, Linda   +4 more
core   +1 more source

Dissociating neural circuits of social and prosocial reward in rat helping behavior

iScience
Summary: Helping behavior in rodents provides a powerful model for studying neurobiological underpinnings of prosocial motivation. Previously, rats allowed to release a trapped conspecific demonstrated prosocial motivation selectively toward ingroup ...
Keren Ruzal, Estherina Trachtenberg, Ben Kantor, Hila Flumin, Adin Roemer, Andres Crespo, Johannes Kohl, Inbal Ben-Ami Bartal   +7 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Behavioral observation of xenopus tadpole swimming for neuroscience labs [PDF]

, 2014
Neuroscience labs benefit from reliable, easily - monitored neural responses mediated by well - studied neural pathways . Xenopus laevis tadpoles have been used as a simple vertebrate model preparation in motor control studies.
Porter, Nicola Jean, Li, Wenchang, Wagner, Monica Anne   +2 more
core  

Tracking spatial patterns and daily modulation of behavior in a natural population of the pulse-type weakly electric fish, Gymnotus omarorum

iScience
Summary: Tracking individual spatial and activity-rest patterns in natural populations is challenging because it is seldom possible to monitor individual-specific traits continuously.
Adriana Migliaro, Federico Pedraja, Stefan Mucha, Jan Benda, Ana Silva   +4 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source