Results 91 to 100 of about 3,317,573 (287)

Clinical and theoretical issues in self-injurious behavior

open access: yesBrazilian Journal of Psychiatry, 1999
This article presents an overview of pathological self-injurious behavior (SIB). Historical and cultural aspects, epidemiology, classification and clinical aspects and pathogenesis are described.
Jose A. Yaryura-Tobias   +2 more
doaj   +1 more source

DIGITAL FILTERS IN BEHAVIORAL RESEARCH [PDF]

open access: yesJournal of the Experimental Analysis of Behavior, 1983
Behavioral control is almost always less than perfect. Rate of response is rarely as constant as it could be even when the greatest care is given to experimental procedures. Experimenters should always attempt to identify the causes of variation. Some fluctuations in response rate will be random, i.e., sometimes positive and sometimes negative, usually
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Bridging psychiatry and rare genetic diseases: a scoping review of therapeutic strategies and diagnostic delay paired with healthcare economic burden analysis

open access: yesOrphanet Journal of Rare Diseases
Rare genetic diseases (RDs) with primary neuropsychiatric symptoms pose unique challenges for diagnosis and management. While the majority of these RDs have neuropsychiatric symptoms that are secondary to the RD, a subset presents with primary ...
Sheldon R. Garrison   +8 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Integrating psychology research and behavioral management

open access: yesPsychology Research and Behavior Management, 2010
Igor ElmanDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USAI am grateful that about two years ago Dove Medical Press offered me the opportunity to edit the Journal of Psychology Research and Behavior Management.
Igor Elman
doaj  

Towards Ecological and Social Balance: Balanced Management for The Conservation of Bilih Fish (Mystacoleusus Padangensis Bleeker) in Singkarak Lake [PDF]

open access: yesBIO Web of Conferences
Symptoms of over exploitation in bilih fish (Mystacoleusus padangensis Bleeker) fishing in Singkarak Lake are indicated by a decline in population and the decreasing size of caught fish.
Nadjib Mochammad   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Strategies for Improving Police Response Models Involving Opioid Overdoses and Overdose Deaths

open access: yesJournal of Multidisciplinary Studies in Human Rights and Science
EN | Abstract: Deflection programs have emerged as a promising approach to addressing the opioid overdose crisis, offering an innovative alternative to traditional criminal justice approaches.
Thomas B. Sease   +6 more
doaj   +1 more source

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