Results 81 to 90 of about 1,165,410 (265)

Integrating psychology research and behavioral management

Psychology Research and Behavior Management, 2010
Igor ElmanDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USAI am grateful that about two years ago Dove Medical Press offered me the opportunity to edit the Journal of Psychology Research and Behavior Management.
Igor Elman
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Strategies for Improving Police Response Models Involving Opioid Overdoses and Overdose Deaths

Journal of Multidisciplinary Studies in Human Rights and Science
EN | Abstract: Deflection programs have emerged as a promising approach to addressing the opioid overdose crisis, offering an innovative alternative to traditional criminal justice approaches.
Thomas B. Sease, Wayne Lehman, Jennifer Pankow, Renee Castillo, Jennifer Becan, Jac Charlier, Kevin Knight   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A rank ordering and analysis of four cognitive-behavioral stress-management competencies suggests that proactive stress management is especially valuable

Scientific Reports
The main objective of this study was to determine the relative value of four cognitive-behavioral competencies that have been shown in empirical studies to be associated with effective stress management.
Robert Epstein, Jessica Aceret, Ciara Giordani, Vanessa R. Zankich, Lynette Zhang   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Reclaiming XAI as an Innovation in Healthcare: Bridging Rule-Based Systems

Algorithms
The adoption of explainable artificial intelligence (XAI) in healthcare has been increasingly framed as dependent on transparency, trustworthiness, and accountability.
Hanvedes Daovisan, Charin Suwanwong, Pitchada Prasittichok, Narulmon Prayai, Phaktada Choowan   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A rank ordering and analysis of nine resilience competencies demonstrates the special importance of thought management in maintaining resilience

Scientific Reports
Resilience has long been known to involve both innate personality characteristics and learned competencies. In the present study, we measured nine trainable competencies that empirical studies suggest are associated with resilience, and then we rank ...
Robert Epstein, Sofia Godoy, Ning Wang, Amanda Newland   +3 more
doaj   +1 more source