Results 111 to 120 of about 7,831,817 (268)

Psychological distress and e-cigarette use among young Australians: An exploratory, qualitative study

Tobacco Induced Diseases
Introduction Emerging research suggests an association between psychological distress and e-cigarette use. However, our understanding of young adults’ experiences of this relationship is limited.
Mary-Ellen E. Brierley, Sara Gaidoni, Michelle I. Jongenelis   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Data Related to Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

, 2019
Here we have included four sets of meta-analysis results: Meta-analysis of discovery and replication cohorts, combining genotyped Exome-chip and Axiom array content for (i) Smoking Initiation, (ii) Cigarettes per day, and (iii) Smoking Cessation, and (iv)
CHD Exome+ consortium, GSCAN, Consortium for Genetics of Smoking Behaviour   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An evaluation of Scottish green health prescriptions using the APEASE criteria

BMC Primary Care
Background Time spent in green space such as parks and forests can have positive effects on physical and mental health. Green Health Partnerships were set up in Scotland to promote use of green space for health improvement.
Neil Howlett, Imogen Freethy, Sian Harding, Adam P. Wagner, Lisa Miners, Honey Anne-Greco, Laura Lamming, Nigel Lloyd, Katherine E. Brown   +8 more
doaj   +1 more source

Perceptions of Australia’s e-cigarette regulations and recommendations for future reforms: a qualitative study of adolescents and adults

BMJ Open
Objective To assess public perceptions of the effectiveness of e-cigarette regulations in minimising use among adolescents and those who have never smoked.
Mary-Ellen E Brierley, Sean J L Yaw, Michelle I Jongenelis   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Evaluation of UnitingCare Men’s Behaviour Change Programs: Stage 2 Report

, 2020
This report provides findings from Stage Two of the evaluation of UnitingCare Men’s Behaviour Change Programs (MBCPs) delivered within five regions across Queensland.
Honorato, Bronwyn, Taylor, Annabel, Lowik, Vicki, Carswell, Sue, Cheyne, Nicola   +4 more
core