Results 81 to 90 of about 7,831,817 (268)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The development of intervention e-learning materials and implementation techniques for cyber-security behaviour change

, 2018
Many organisations show compliance in running security awareness programmes, but this does not necessarily mean end users will change their behavior. is highlights one of the main challenges in cyber security.
Skinner, Tiffany, Taylor-Jackson, Jacqui (R19920), McAlaney, John, Dale, John   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An ontological framework for organising and describing behaviours: The Human Behaviour Ontology [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research
Background Human behaviours have been classified in domains such as health, occupation and sustainability. We aimed to develop a broadly applicable behavioural framework to facilitate integrating evidence across domains.
Alison J. Wright, Robert West, Janna Hastings, Lisa Zhang, Oscar Castro, Marta M. Marques, Emily Hayes, Elizabeth Corker, Micaela Santilli, Susan Michie, Marie Johnston, Gabriella Stuart, Paulina M. Schenk   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The CHARMS pilot study: a multi-method assessment of the feasibility of a sexual counselling implementation intervention in cardiac rehabilitation in Ireland

Pilot and Feasibility Studies, 2018
Background Many people living with cardiovascular disease (CVD) are affected by sexual problems associated with the condition. International guidelines recommend all patients with CVD should receive sexual counselling, yet this is rarely provided by ...
Patrick J. Murphy, Chris Noone, Maureen D’Eath, Dympna Casey, Sally Doherty, Tiny Jaarsma, Andrew W. Murphy, Martin O’Donnell, Noeleen Fallon, Paddy Gillespie, Amirhossein Jalali, Jenny Mc Sharry, John Newell, Elaine Toomey, Elaine E. Steinke, Molly Byrne   +15 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

An ontology of mechanisms of action in behaviour change interventions [version 2; peer review: 2 approved]

Wellcome Open Research
Background Behaviour change interventions influence behaviour through causal processes called “mechanisms of action” (MoAs). Reports of such interventions and their evaluations often use inconsistent or ambiguous terminology, creating problems for ...
Candice Moore, Alison J. Wright, Verena Schneider, Robert West, Emily Hayes, Janna Hastings, Ella Howes, Susan Michie, Fabiana Lorencatto, Paulina M. Schenk   +9 more
doaj   +1 more source