Results 111 to 120 of about 1,434,057 (290)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Survival of the Fittest: Evidence-based Interventions for Physical Inactivity Amongst Student Populations

JANZSSA, 2017
Lack of physical activity is a problem amongst student populations given their large proportion of desk-bound activity. Attrition from physical activity programs is widespread.
Stephanie C. Black
doaj   +1 more source

Development of a theory-informed implementation intervention to improve the triage, treatment and transfer of stroke patients in emergency departments using the Theoretical Domains Framework (TDF): the T3 Trial

Implementation Science, 2017
Background Theoretical frameworks and models based on behaviour change theories are increasingly used in the development of implementation interventions.
Louise E. Craig, Natalie Taylor, Rohan Grimley, Dominique A. Cadilhac, Elizabeth McInnes, Rosemary Phillips, Simeon Dale, Denise O’Connor, Chris Levi, Mark Fitzgerald, Julie Considine, Jeremy M. Grimshaw, Richard Gerraty, N. Wah Cheung, Jeanette Ward, Sandy Middleton   +15 more
doaj   +1 more source

Literature Review - Health behaviour change models and approaches for families and young people to support HEAT 3: Child Healthy Weight Programmes [PDF]

, 2010
The literature review has been commissioned by NHS Health Scotland to review the health behaviour change models and approaches for families, children and young people to support the development and delivery of effective child healthy weight programmes ...
Sahota, P, Woodward, J, Wordley, J
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Development of a behaviour change intervention to increase care home staff influenza vaccination uptake

International Journal of Nursing Studies Advances
Background: To protect care home residents the World Health Organisation recommends that 75 % of care home staff are vaccinated for influenza. In the UK this value is less than 30 %.
Amrish Patel, Sion Scott, Alys Wyn Griffiths, David Wright   +3 more
doaj   +1 more source

The Development of Intervention E-Learning Materials and Implementation Techniques For Cyber-Security Behaviour Change [PDF]

, 2018
Many organisations show compliance in running security awareness programmes, but this does not necessarily mean end users will change their behavior. This highlights one of the main challenges in cyber security.
Dale, J., McAlaney, John, Skinner, T., Taylor, Jacqui   +3 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source