Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice. [PDF]
Brain, 2022 Hurley MJ +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
IL-4Rα deletion disrupts psychomotor performance and reference memory in mice while sparing behavioural phenotype associated with spatial learning. [PDF]
Brain Behav Immun, 2021 Brombacher TM +6 more
europepmc +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Behavioural phenotypes: from models to intervention.
Journal of intellectual disability research : JIDR, 2011 A notable trend in the Society for the Study of Behavioural Phenotypes Scientific Symposium abstracts that are published annually in this special edition, is the increase in the number of papers that refer explicitly to intervention for intellectual disability at a level other than behaviour change.
Heussler, H. S., Oliver, C.
openaire +4 more sources
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Novel behavioural characteristics of female APPSwe/PS1ΔE9 double transgenic mice
, 2014 Murine models are commonly used to evaluate progression of Alzheimer's disease. APPSwe/PS1ΔE9 (APPxPS1) mice have previously been reported to demonstrate impaired learning and memory in the Morris water maze test.
Logge, Warren +4 more
core +1 more source
Rett syndrome: Evidence for behavioural phenotype [PDF]
, 2001 The purpose of this thesis was to determine whether there is a specific behavioural phenotype associated with Rett syndrome (RS). In the first of two studies, behavioural and emotional features were assessed in girls with RS and girls with severe to ...
Mount, Rebecca Helen
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Behavioural correlates of the equine stereotypy phenotype
, 2008 Stereotypic behaviour is characterised as repetitive, topographically invariant, rigid behaviour patterns, often displayed by captive, domestic and laboratory animals.
Parker, Matthew Oliver
core +1 more source