Results 91 to 100 of about 996,273 (286)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse. [PDF]

Genes (Basel), 2023
Lawther AJ, Zieba J, Fang Z, Furlong TM, Conn I, Govindaraju H, Choong LLY, Turner N, Siddiqui KS, Bridge W, Merlin S, Hyams TC, Killingsworth M, Eapen V, Clarke RA, Walker AK.   +15 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Energy billing survey and RCTs

, 2022
The Behavioural Economics Team of the Australian Government (BETA) partnered with the Australian Energy Regulator (AER) to apply behavioural insights to the design of energy bills.
Behavioural Economics Team of the Australian Government
core   +1 more source

A diabetes-like biochemical and behavioural phenotype of Drosophila induced by predator stress. [PDF]

Proc Biol Sci, 2023
Krama T, Bahhir D, Ots L, Popovs S, Bartkevičs V, Pugajeva I, Krams R, Merivee E, Must A, Rantala MJ, Krams I, Jõers P.   +11 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Parental effects alter the adaptive value of an adult behavioural trait

eLife, 2015
The parents' phenotype, or the environment they create for their young, can have long-lasting effects on their offspring, with profound evolutionary consequences.
Rebecca M Kilner, Giuseppe Boncoraglio, Jonathan M Henshaw, Benjamin JM Jarrett, Ornela De Gasperin, Alfredo Attisano, Hanna Kokko   +6 more
doaj   +1 more source

Annotation: Behaviour Phenotypes: A window On to the Biology of Behavior

Journal of Child Psychology and Psychiatry, 1996
Characteristic behavioural pattern (including cognitive processes and social interactions) have been reported in a number of syndromes arising from genetic or chromosomal abnormalities, suggesting that molecular analysis of the underlying defect could reveal the biological basis of the behavioural phenotype.
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source