Results 101 to 110 of about 1,025,641 (274)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioural phenotype. [PDF]

Brain Commun, 2022
Nagai M, Iemura K, Kikkawa T, Naher S, Hattori S, Hagihara H, Nagata KI, Anzawa H, Kugisaki R, Wanibuchi H, Abe T, Inoue K, Kinoshita K, Miyakawa T, Osumi N, Tanaka K.   +15 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

phenotype

, 2012
Phenotype data for 280 lines in the Nebraska Wheat Breeding Program measured in 2010 at nine testing ...
Jose Crossa (3294642), Baenziger, P. S., Dong Wang (73290), Wang, Dong, Ibrahim El-Basyoni (3294645), P. S. Baenziger (3294651), Crossa, Jose, Dweikat, I., I. Dweikat (3294648), El-Basyoni, Ibrahim, Kent Eskridge (175928), Eskridge, Kent   +11 more
core   +1 more source

Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice. [PDF]

Brain, 2022
Hurley MJ, Deacon RMJ, Chan AWE, Baker D, Selwood DL, Cogram P.   +5 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

IL-4Rα deletion disrupts psychomotor performance and reference memory in mice while sparing behavioural phenotype associated with spatial learning. [PDF]

Brain Behav Immun, 2021
Brombacher TM, Ajonijebu DC, Scibiorek M, Berkiks I, Moses BO, Mpotje T, Brombacher F.   +6 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

eLife
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug development.
Thomas J O'Brien, Ida L Barlow, Luigi Feriani, André EX Brown   +3 more
doaj   +1 more source

Behavioural phenotypes: from models to intervention.

Journal of intellectual disability research : JIDR, 2011
A notable trend in the Society for the Study of Behavioural Phenotypes Scientific Symposium abstracts that are published annually in this special edition, is the increase in the number of papers that refer explicitly to intervention for intellectual disability at a level other than behaviour change.
Heussler, H. S., Oliver, C.
openaire   +4 more sources