Results 101 to 110 of about 996,273 (286)

Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype. [PDF]

Mol Psychiatry, 2022
Fernandes DJ, Spring S, Corre C, Tu A, Qiu LR, Hammill C, Vousden DA, Spencer Noakes TL, Nieman BJ, Bowdish DME, Foster JA, Palmert MR, Lerch JP.   +12 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts [PDF]

, 2009
Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix ...
Christopher P Denton, Abraham, DJ, Denton, CP, Mark Eastwood, Sonali Sonnylal, Shi-Wen, X., Liu Shangxi, Leask, A., Abraham David J., Liu, SX, Shi-wen, X, Denton, C.P., Shangxi Liu, Sonnylal, S, Abraham, D.J., David J Abraham, Liu, S., Andrew Leask, Shi-wen Xu, Denton Christopher P., Eastwood Mark, Eastwood, M, Leask, A, Eastwood, M., Sonnylal Sonali, Leask Andrew, Sonnylal, S.   +26 more
core   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Slow physical growth, delayed reflex ontogeny and permanent behavioural as well as cognitive impairments in rats following intra-generational protein malnutrition

Frontiers in Neuroscience, 2015
Environmental stressors including protein malnutrition (PMN) during pre-, neo- and post-natal age have been documented to affect cognitive development and cause increased susceptibility to neuropsychiatric disorders. Most studies have addressed either of
AIJAZ AHMAD NAIK, Ishan ePatro, Nisha ePatro   +2 more
doaj   +1 more source

Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioural phenotype. [PDF]

Brain Commun, 2022
Nagai M, Iemura K, Kikkawa T, Naher S, Hattori S, Hagihara H, Nagata KI, Anzawa H, Kugisaki R, Wanibuchi H, Abe T, Inoue K, Kinoshita K, Miyakawa T, Osumi N, Tanaka K.   +15 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A worldwide correlation of lactase persistence phenotype and genotypes [PDF]

, 2010
Background: The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research.
Jones Bryony L, Ingram, C.J.E., Thomas, M.G., Swallow Dallas M, Jones, B.L., Dallas M Swallow, Itan, Y., Yuval Itan, Swallow, D.M., Itan Yuval, Thomas Mark G, Catherine JE Ingram, Ingram Catherine JE, Bryony L Jones, Mark G Thomas   +14 more
core   +1 more source

High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

eLife
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug development.
Thomas J O'Brien, Ida L Barlow, Luigi Feriani, André EX Brown   +3 more
doaj   +1 more source

Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice

Behavioral and Brain Functions, 2012
Background Previous studies have demonstrated a profound lack of habituation in 129P3 mice compared to the habituating, but initially more anxious, BALB/c mice. The present study investigated whether this non-adaptive phenotype of 129P3 mice is primarily
Salomons Amber R, Pinzon Nathaly, Boleij Hetty, Kirchhoff Susanne, Arndt Saskia S, Nordquist Rebecca E, Lindemann Lothar, Jaeschke Georg, Spooren Will, Ohl Frauke   +9 more
doaj   +1 more source