Results 81 to 90 of about 996,273 (286)

phenotype

, 2015
phenotype and experimental ...
Ilga Porth (138357), Jaroslav Klapste (3298053), Yousry El-Kassaby (3298056), Klapste, Jaroslav, Charles Chen (121346), Jaquish, Barry, Gamal El-Dien, Omnia, Porth, Ilga, Omnia Gamal El-Dien (3245454), El-Kassaby, Yousry, Chen, Charles, Blaise Ratcliffe (3245460), Barry Jaquish (138362), Ratcliffe, Blaise   +13 more
core   +1 more source

Depletion of FKBP51 in female mice shapes HPA axis activity.

PLoS ONE, 2014
Psychiatric disorders such as depressive disorders and posttraumatic stress disorder are a major disease burden worldwide and have a higher incidence in women than in men. However, the underlying mechanism responsible for the sex-dependent differences is
Lianne Hoeijmakers, Daniela Harbich, Bianca Schmid, Paul J Lucassen, Klaus V Wagner, Mathias V Schmidt, Jakob Hartmann   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

phenotype

, 2012
Phenotype data for 280 lines in the Nebraska Wheat Breeding Program measured in 2010 at nine testing ...
Jose Crossa (3294642), Baenziger, P. S., Dong Wang (73290), Wang, Dong, Ibrahim El-Basyoni (3294645), P. S. Baenziger (3294651), Crossa, Jose, Dweikat, I., I. Dweikat (3294648), El-Basyoni, Ibrahim, Kent Eskridge (175928), Eskridge, Kent   +11 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

GenMoat/Behavioural-Synchrony-: v2.0

, 2022
Full Changelog: https://github.com/GenMoat/Behavioural-Synchrony-/commits/v2.
Genevieve Moat
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes

BMC Neuroscience, 2018
Background Epidemiological surveys and studies with animal models have established a relationship between maternal stress and affective disorders in their offspring.
Sheng Wei, Zifa Li, Meng Ren, Jieqiong Wang, Jie Gao, Yinghui Guo, Kaiyong Xu, Fang Li, Dehao Zhu, Hao Zhang, Rongju Lv, Mingqi Qiao   +11 more
doaj   +1 more source