Results 61 to 70 of about 996,273 (286)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype [PDF]

, 2011
Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical
Lopes-Cendes, Iscia, Odile Russaouen, Cécile Cazeneuve, Cazeneuve, Cécile, Walker R.H., Russaouen O., Bader B., Guilherme Riccioppo Rodrigues, Brice A., Russaouen, Odile, Tumas, Vitor, Wilson Marques Jr., Rodrigues G.R., Iscia Lopes-Cendes, Danek, Adrian, Adrian Danek, MARQUES JR., Wilson, Brice, Alexis, Marques Jr. W., Marques, Wilson, Vitor Tumas, Walker, Ruth H., Bader, Benedikt, Benedikt Bader, Danek A., Cazeneuve C., Ruth H. Walker, Riccioppo Rodrigues, Guilherme, RODRIGUES, Guilherme Riccioppo, Alexis Brice, Tumas V., Lopes-Cendes I.   +31 more
core   +1 more source

Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment. [PDF]

PLoS ONE, 2016
Alzheimer's disease (AD) is a devastating illness characterized by a progressive loss of cognitive, social, and emotional functions, including memory impairments and more global cognitive deficits.
Louise Ørum Olesen, Elena V Bouzinova, Maurizio Severino, Mithula Sivasaravanaparan, Jørgen Bo Hasselstrøm, Bente Finsen, Ove Wiborg   +6 more
doaj   +1 more source

A phenotypic analysis of GP-evolved team behaviours [PDF]

Proceedings of the 9th annual conference on Genetic and evolutionary computation, 2007
This paper presents an approach to analyse the behaviours of teams of autonomous agents who work together to achieve a common goal. The agents in a team are evolved together using a genetic programming (GP) [8] approach where each team of agents is represented as a single GP tree or chromosome.
Darren Doherty, Colm O'Riordan
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level.

PLoS Biology, 2022
The phenotype of an organism results from its genotype and the influence of the environment throughout development. Even when using animals of the same genotype, independent studies may test animals of different phenotypes, resulting in poor ...
Ivana Jaric, Bernhard Voelkl, Melanie Clerc, Marc W Schmid, Janja Novak, Marianna Rosso, Reto Rufener, Vanessa Tabea von Kortzfleisch, S Helene Richter, Manuela Buettner, André Bleich, Irmgard Amrein, David P Wolfer, Chadi Touma, Shinichi Sunagawa, Hanno Würbel   +15 more
doaj   +1 more source

Behavioural phenotyping assays for mouse models of autism [PDF]

Nature Reviews Neuroscience, 2010
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1 in 100-150 individuals. Diagnosis is based on three categories of behavioural criteria: abnormal social interactions, communication deficits and repetitive behaviours.
Jill L, Silverman, Mu, Yang, Catherine, Lord, Jacqueline N, Crawley   +3 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Behavioural phenotype of sensitisation at micro and macro level.

, 2013
Behavioural phenotype of sensitisation at micro and macro level.
Nele Jacobs (35964), Evert Thiery (283069), Johanna T. W. Wigman (283064), Inez Myin-Germeys (283072), Marieke Wichers (283066), Catherine Derom (283068), Jim van Os (114336), Dina Collip (283065)   +7 more
core   +1 more source

Behavioural predictability in chickens in response to anxiogenic stimuli is influenced by maternal corticosterone levels during egg formation

Scientific Reports
Across species, prenatal maternal stress has been shown to create heterogeneity in behavioural phenotypes. Research has recently highlighted that individuals vary in how predictable they are in their behavioural responses.
Diego Stingo-Hirmas, Lars Rönnegård, Felipe Cunha, Dominic Wright, Rie Henriksen   +4 more
doaj   +1 more source