Results 41 to 50 of about 1,025,641 (274)

Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD). [PDF]

, 2009
Although there is evidence for the involvement of genes of serotonergic and dopaminergic systems in the manifestation of the Behavioural and Psychological Symptoms in Dementia (BPSD), genetic association studies are contradictory.
Belinda Martin, John Powell, Brian Lawlord, Suzanne Reeves, Nicola Archer, Michael J. Owen, Julie Williams, Paul hollingworth, Michael Gill, Simon Lovestone, Michelle Lupton, Petroula Proitsi, Gillian Hamilton   +12 more
core  

Extensive behavioural divergence following colonisation of the freshwater environment in threespine sticklebacks.

PLoS ONE, 2014
Colonisation of novel environments means facing new ecological challenges often resulting in the evolution of striking divergence in phenotypes.
Carole Di-Poi, Jennyfer Lacasse, Sean M Rogers, Nadia Aubin-Horth   +3 more
doaj   +1 more source

Phenotypic plasticity of a cooperative behaviour in bacteria

Journal of Evolutionary Biology, 2009
AbstractThere is strong evidence that natural selection can favour phenotypic plasticity as a mechanism to maximize fitness in animals. Here, we aim to investigate phenotypic plasticity of a cooperative trait in bacteria – the production of an iron‐scavenging molecule (pyoverdin) by Pseudomonas aeruginosa.
R. KÜMMERLI, N. JIRICNY, L. S. CLARKE, S. A. WEST, A. S. GRIFFIN   +4 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Behavioural and physiological responses to stressors in sheep with temperament classified by genotype or phenotype

Scientific Reports
The single nucleotide polymorphism (SNP) rs107856856, located in the tryptophan hydroxylase-2 gene, is associated with the behavioural phenotype for sheep temperament measured at weaning. Here, we tested the association between that SNP and physiological
Yuri Kitagawa, Shane K. Maloney, Kelsey R. Pool, Dane Webster, Satoshi Ohkura, Dominique Blache, Luoyang Ding   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data. [PDF]

, 2013
The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations ...
Smith, C.L., Brown, D. L., Jackson, Andrew P., Leeuw, Nicole de, Doelken, S. C., Black, G.C.M., Campbell, J., Mansour, S, Jackson, Andrew P, Kelly, Anne M., Martin, CL, Kohler, S., Martin, Christa L, Ruef, Barbara J., Jackson, AP, Wright, Caroline F., Girdea, M., Mungall, C. J., Park, Soo-Mi, Girdea, M, Jähn, Johanna, Eppig, J.T., Washingthon, Nicole L., Girdea, Marta, Ouwehand, W.H., Gkoutos, G. V.; id_orcid, Smith, Cynthia, Campbell, Jennifer, Campbell, J, de Leeuw, N, Hurst, Jane A, Wapner, RJ, Scott, Richard H., Westerfield, M, Gkoutos, GV, Brudno, M, Robinson, Peter N., Kelly, AM, Riggs, E.R., Moss, C., Jackson, L. G., Mansour, Sahar, Doelken, S.C., Jahn, J., Wright, Caroline F, FitzPatrick, D. R., Vooren, Steven Van, Ruef, B.J., Kelly, A.M., Ruef, BJ, Scott, R. H., Washingthon, NL, Ledbetter, DH, Freson, K., FitzPatrick, DR, Smith, CL, Firth, H.V., Moss, Celia, Hurst, J. A., FitzPatrick, D.R., Haendel, M., Jackson, L.G., Eppig, J. T., Ruef, B. J., Sisodiya, S., Park, S.M., Bailleul-Forestier, Isabelle, Van Vooren, S., Jackson, Laird G, Köhler, S, Wilkie, Andrew O M, Lewis, SE, Martin, C.L., Robinson, P. N., Mumford, A, Gkoutos, Georgios V., Smedley, Damian, Ouwehand, Willem H, Mumford, Andrew, Firth, Helen V, Haendel, M, Firth, H. V., Hurst, JA, Mungall, C.J., Vulto-van Silfhout, AT, Doelken, Sandra C, Lewis, S. E., Brown, Danielle L., Smedley, D., Vulto-Van Silfhout, Anneke T., Park, Soo Mi, Freson, K, Wilkie, A.O., Martin, Christa L., Riggs, ER, de Vries, Bert B A, Mungall, Christopher J., Vulto-van Silfhout, Anneke T, Ouwehand, W. H., Schofield, P., Vulto-van Silfhout, A. T., Ouwehand, WH, Martin, C. L., Lewis, Suzanna E, Hurst, J.A., Firth, HV, Mungall, Christopher J, Park, S. M., Wilkie, A. O., Westerfield, M., Kelly, A. M., Helbig, Ingo, Jackson, A. P., Doelken, SC, Helbig, I., Wright, C. F., Wright, CF, Schofield, Paul, Firth, Helen V., Köhler, Sebastian, Ledbetter, D.H., Eppig, Janan T., Riggs, E. R., Fitzpatrick, David R, Doelken, Sandra C., Eppig, Janan T, Mumford, A., Vooren, S. van der, Black, G. C., Sisodiya, Sanjay, Smith, Cynthia L, Washingthon, N. L., Kelly, Anne M, Lewis, S.E., de Vries, B. B., Gkoutos, Georgios V, Moss, C, Mansour, S., Riggs, Erin Rooney, Wapner, Ronald J., Black, GC, Scott, R.H., Scott, RH, Robinson, Peter N, Helbig, I, Bauer, Sebastian, Bailleul-Forestier, I., Jähn, J, Hurst, Jane A., Wapner, R. J., Ledbetter, D. H., Jackson, A.P., Ruef, Barbara J, Westerfield, Monte, Jackson, Laird G., Lewis, Suzanna E., de Vries, BB, Fitzpatrick, David R., Vries, B. de, Black, Graeme C M, Gkoutos, G.V., Brudno, Michael, Smith, Cynthia L., Silfhout, A.T. van, Smith, C. L., Brown, Danielle L, Ledbetter, David H, Wright, C.F., Brown, D.L., Mungall, CJ, Schofield, P, Bailleul-Forestier, I, Bauer, S., Haendel, Melissa, Robinson, P.N., Van Vooren, S, Ledbetter, David H., Eppig, JT, Washingthon, Nicole L, Smedley, D, Park, SM, Robinson, PN, Leeuw, N. de, de Leeuw, N., Scott, Richard H, Brudno, M., Jackson, LG, Wapner, R.J., Brown, DL, Wapner, Ronald J, Bauer, S, Mumford, Andrew D, Washingthon, N.L., Sisodiya, S, Freson, Kathleen, Ouwehand, Willem H., Wilkie, AO   +196 more
core   +1 more source

The behavioural and cognitive phenotype of Smith-Magenis syndrome [PDF]

, 2012
Background: Attention-seeking and impulsivity are reported to be problematic in Smith-Magenis syndrome (SMS) and have been linked to other challenging behaviours including self-injury and aggression.
Wilde, Lucy Victoria
core   +7 more sources

Flexible males, proactive females: increased boldness/exploration damping with time in male but not female colonists

Royal Society Open Science
Individuals colonizing new areas during range expansion encounter challenging and unfamiliar environments, suggesting that colonists should differ in behavioural traits from residents of source populations.
Andrey V. Tchabovsky, Elena N. Surkova, Ludmila E. Savinetskaya, Ivan S. Khropov   +3 more
doaj   +1 more source

Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial.

PLoS ONE, 2012
BackgroundThe behavioural impact of pharmacogenomics is untested. We tested two hypotheses concerning the behavioural impact of informing smokers their oral dose of NRT is tailored to analysis of DNA.Methods and findingsWe conducted an RCT with smokers ...
Theresa M Marteau, Paul Aveyard, Marcus R Munafò, A Toby Prevost, Gareth J Hollands, David Armstrong, Stephen Sutton, Chloe Hill, Elaine Johnstone, Ann Louise Kinmonth   +9 more
doaj   +1 more source