Results 51 to 60 of about 996,273 (286)

Genetic predisposition to obesity affects behavioural traits including food reward and anxiety-like behaviour in rats [PDF]

, 2017
Here we sought to define behavioural traits linked to anxiety, reward, and exploration in different strains of rats commonly used in obesity research.
Heike Vogel, Maria Kraemer, Dickson, Suzanne L., Vogel, Heike, Rabasa, Cristina, Roger A.H. Adan, Askevik, Kaisa, Dickson, Suzanne L.,, Rabasa-Papio, Cristina,, Vogel, Heike,, Kraemer, Maria, Cristina Rabasa, Kaisa Askevik, Adan, R. A. H., Adan, Roger A.H., Kraemer, Maria,, Suzanne L. Dickson, Askevik, Kaisa,   +17 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cognitive comorbidities of experimental absence seizures are independent of anxiety

Neurobiology of Disease, 2023
Typical absence seizures (ASs) are brief periods of lack of consciousness, associated with 2.5–4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children and teenagers.
Mariana Neuparth-Sottomayor, Carolina C. Pina, Tatiana P. Morais, Miguel Farinha-Ferreira, Daniela Sofia Abreu, Filipa Solano, Francisco Mouro, Mark Good, Ana Maria Sebastião, Giuseppe Di Giovanni, Vincenzo Crunelli, Sandra H. Vaz   +11 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The Fragile X Syndrome: Behavioral Phenotype and Learning Disabilities

Siglo Cero, 2016
In this article, we describe the behavioral phenotype of individuals with Fragile X Syndrome and its impact in the educational scope. This syndrome is characterized by difficulties in sensory integration, cognitive deficits (verbal reasoning, abstract ...
Claudia GRAU RUBIO, María FERNÁNDEZ HAWRYLAK, José Luis CUESTA GÓMEZ   +2 more
doaj   +1 more source

Childhood neurodegeneration associated with a specific UBTF variant: a new case report and review of the literature

BMC Neurology, 2020
Background A new monogenic neurodegenerative disease affecting ribosomal metabolism has recently been identified in association with a monoallelic UBTF putative gain of function variant (NM_001076683.1:c.628G>A, hg19). Phenotype is consistent among these
Filipa Bastos, Mathieu Quinodoz, Marie-Claude Addor, Beryl Royer-Bertrand, Heidi Fodstad, Carlo Rivolta, Claudia Poloni, Andrea Superti-Furga, Eliane Roulet-Perez, Sebastien Lebon   +9 more
doaj   +1 more source

Behavioural phenotypes in genetic syndromes: a window on to the biology of behaviour [PDF]

Annals of General Psychiatry, 2006
Results They were organized by dividing them into three groups according to the biological characteristics recognized to date: a) BP associated to genetic diseases with an identified biological basis (syndromes such as Lesch Nyhan, Rett, fragile X, tuberous sclerosis complex, Noonan, Sotos, Aicardi, Angel man, Prader Willi, Williams, Down, Smith ...
Akbarzadeh Reyhaneh, Akbarzadeh Reza, Akbarzadeh Marjaneh   +2 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Behavioural phenotype of Cornelia de Lange syndrome: Case control study [PDF]

, 2008
BACKGROUND: Cornelia de Lange syndrome is associated with abnormalities on chromosomes 5, 10 and X. AIMS: To delineate the behavioural phenotype of Cornelia de Lange syndrome with specific reference to autistic-spectrum disorder.
Arron, Kate, Oliver, C, Oliver, Christopher, Sloneem, J, Hall, S, Sloneem, Jennifer, Arron, K   +6 more
core   +1 more source

Applying psycho-behavioural phenotyping in obesity characterization

Reviews in Endocrine and Metabolic Disorders, 2023
AbstractIndividual differences in obesity, beyond being explained by metabolic and medical complications, are understood by alterations in eating behaviour which underlie psychological processes. From this psychological perspective, studies have identified several potential characteristic features at the psycho-behavioural level that could additionally
Lucía Camacho-Barcia, Ignacio Lucas, Romina Miranda-Olivos, Susana Jiménez-Murcia, Fernando Fernández-Aranda   +4 more
openaire   +3 more sources