Results 71 to 80 of about 996,273 (286)

Phaeomelanin matters: Redness associates with inter-individual differences in behaviour and feather corticosterone in male scops owls (Otus scops).

PLoS ONE, 2020
Individuals within populations often show consistent variation in behavioural and physiological traits which are frequently inter-correlated, potentially leading to phenotypic integration.
Ángel Cruz-Miralles, Jesús M Avilés, Olivier Chastel, Mónica Expósito-Granados, Deseada Parejo   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The behavioural phenotype of 14-month-old female TAU58/2 transgenic mice

, 2021
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) exhibit intracellular inclusions [neurofibrillary tangles (NFT's)] of microtubule-associated protein tau that contributes to neuronal dysfunction and death.
Ittner, Arne, Ittner, Lars M., Przybyla, Magdalena, Watt, Georgia (R20514), Masanetz, Rebecca, Karl, Tim (R18316), Kreilaus, Fabian (R18953)   +6 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Host plant effects on the behavioural phenotype of a Chrysomelid

, 2017
Müller T, Müller C. Host plant effects on the behavioural phenotype of a Chrysomelid. Ecological Entomology.
Müller, Thorben, THORBEN MÜLLER, CAROLINE MÜLLER, Müller, Caroline   +3 more
core   +1 more source

Host genetics maps to behaviour and brain structure in developmental mice

Behavioral and Brain Functions
Gene-environment interactions in the postnatal period have a long-term impact on neurodevelopment. To effectively assess neurodevelopment in the mouse, we developed a behavioural pipeline that incorporates several validated behavioural tests to measure ...
Sarah Asbury, Jonathan K. Y. Lai, Kelly C. Rilett, Zeeshan Haqqee, Benjamin C. Darwin, Jacob Ellegood, Jason P. Lerch, Jane A. Foster   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The behavioural phenotype of children with charge syndrome [PDF]

Background: CHARGE syndrome is a highly variable, rare multisystemic condition, with an estimated prevalence of 1 in 8500 live births. Given the multitude of medical difficulties experienced by children with CHARGE syndrome, research to date has focused ...
Thomas, Andrea
core   +5 more sources

Genetics of Frontotemporal Lobar Degeneration

Frontiers in Neurology, 2012
Frontotemporal Lobar Degeneration (FTLD) is the most frequent neurodegenerative disorder with a presenile onset. It presents with a spectrum of clinical manifestations, ranging from behavioural and executive impairment to language disorders and motor ...
Daniela eGalimberti, Elio eScarpini
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source