Results 71 to 80 of about 1,025,641 (274)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Behavioural predictability in chickens in response to anxiogenic stimuli is influenced by maternal corticosterone levels during egg formation

Scientific Reports
Across species, prenatal maternal stress has been shown to create heterogeneity in behavioural phenotypes. Research has recently highlighted that individuals vary in how predictable they are in their behavioural responses.
Diego Stingo-Hirmas, Lars Rönnegård, Felipe Cunha, Dominic Wright, Rie Henriksen   +4 more
doaj   +1 more source

The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level.

PLoS Biology, 2022
The phenotype of an organism results from its genotype and the influence of the environment throughout development. Even when using animals of the same genotype, independent studies may test animals of different phenotypes, resulting in poor ...
Ivana Jaric, Bernhard Voelkl, Melanie Clerc, Marc W Schmid, Janja Novak, Marianna Rosso, Reto Rufener, Vanessa Tabea von Kortzfleisch, S Helene Richter, Manuela Buettner, André Bleich, Irmgard Amrein, David P Wolfer, Chadi Touma, Shinichi Sunagawa, Hanno Würbel   +15 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Misleading behavioural phenotype with adenylosuccinate lyase deficiency [PDF]

European Journal of Human Genetics, 2008
Adenylosuccinate lyase deficiency is a rare autosomal disorder of de novo purine synthesis, which results in the accumulation of succinylpurines in body fluids. Patients with adenylosuccinate lyase deficiency show a variable combination of mental retardation, epilepsy and autistic features and are usually discovered during screens for unexplained ...
Cyril, Gitiaux, Irène, Ceballos-Picot, Sandrine, Marie, Vassili, Valayannopoulos, Marlène, Rio, Séverine, Verrieres, Jean François, Benoist, Marie Françoise, Vincent, Isabelle, Desguerre, Nadia, Bahi-Buisson   +9 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Host genetics maps to behaviour and brain structure in developmental mice

Behavioral and Brain Functions
Gene-environment interactions in the postnatal period have a long-term impact on neurodevelopment. To effectively assess neurodevelopment in the mouse, we developed a behavioural pipeline that incorporates several validated behavioural tests to measure ...
Sarah Asbury, Jonathan K. Y. Lai, Kelly C. Rilett, Zeeshan Haqqee, Benjamin C. Darwin, Jacob Ellegood, Jason P. Lerch, Jane A. Foster   +7 more
doaj   +1 more source

Phaeomelanin matters: Redness associates with inter-individual differences in behaviour and feather corticosterone in male scops owls (Otus scops).

PLoS ONE, 2020
Individuals within populations often show consistent variation in behavioural and physiological traits which are frequently inter-correlated, potentially leading to phenotypic integration.
Ángel Cruz-Miralles, Jesús M Avilés, Olivier Chastel, Mónica Expósito-Granados, Deseada Parejo   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source