Results 121 to 130 of about 11,513 (248)

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, Volume 12, Issue 35, September 18, 2025.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Oxidative Phosphorylation in Uncoupled Mitochondria

BioEssays, Volume 47, Issue 9, September 2025.
Brown adipose tissue (BAT) mediates non‐shivering thermogenesis (NST) through activation of uncoupling protein 1 (UCP1). Due to the uncoupled nature of BAT, oxidative phosphorylation is an underappreciated contributor to NST. Here, we discuss the implications of Inhibitory Factor 1 modulation, an endogenous inhibitor of ATP synthase, for BAT physiology.
Henver S. Brunetta, Marcelo A. Mori, Alexander Bartelt   +2 more
wiley   +1 more source

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? [PDF]

, 2017
Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological ...
Agra, Agra, Alexander, Alexander, Alexander, Alexopoulos, Arora, Baessler, Bakkum, Balcioglu, Berridge, Berry, Bers, Bers, Bełtowski, Bian, Burgeiro, Burridge, Castro, Chechi, Cheng, Chilukoti, Chiu, Daya, Dekker, Deng, Deng, Dobrzynski, Dong, Du, Eisner, Elie, Elisha, Engler, Fain, Fandino-Vaquero, Fernandez-Trasancos, Fosshaug, Frankel, Furuhashi, Gaborit, Gaborit, Gao, Georgiou, Ghantous, Gho, Goncalves, Greif, Greulich, Greulich, Greulich, Gruen, Guauque-Olarte, Haemers, Harada, Hassan, Hatem, Hatem, Hatem, Heijman, Heijman, Hua, Hung, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Imoto-Tsubakimoto, Iozzo, Itoh, Janik, Karastergiou, Kaushik, Kazumi, Kim, Kim, Kitagawa, Kleinz, Kusayama, Lage, Lamounier-Zepter, Lamounier-Zepter, Langheim, Leeper, Li, Lim, Lip, Look, MacQueen, Maghbooli, Mahabadi, Mahabadi, Marchington, Marchington, Margaritis, Martinsen, Matloch, Mattacks, Mattacks, Mattacks, Mazurek, Mazurek, Mazzoccoli, McAninch, Mookadam, Nakanishi, Nevelsteen, Nicholls, O'Connell, Pang, Paolisso, Parisi, Pezeshkian, Phillips, Pierdomenico, Pond, Pontes Soares, Prati, Rabkin, Rachwalik, Rainwater, Rajapurohitam, Rodriguez-Penas, Sacks, Sacks, Sacks, Sade, Salgado-Somoza, Samanta, Sarin, Scimia, Shapira-Schweitzer, Shibasaki, Shimabukuro, Siegel-Axel, Silaghi, Smith, Song do, Southan, Spiroglou, Szokodi, Takebayashi, Talman, Teijeira-Fernandez, Vacca, Venteclef, Viscogliosi, Voigt, Vural, Weikert, Westcott, White, Willens, Wong, Xu, Yamaguchi, Yañez-Rivera, Ye, Yilmaz, Zdychova, Zeng, Zhou   +164 more
core   +1 more source

Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose Tissue Homeostasis in the Context of Beigeing

Cells, 2019
Obesity and adipocyte malfunction are related to and arise as consequences of disturbances in signaling pathways. Tyrosine kinase substrate with four Src homology 3 domains (Tks4) is a scaffold protein that establishes a platform for signaling cascade ...
Virag Vas, Tamás Háhner, Gyöngyi Kudlik, Dávid Ernszt, Krisztián Kvell, Dániel Kuti, Krisztina J. Kovács, József Tóvári, Mária Trexler, Balázs L. Merő, Bálint Szeder, Kitti Koprivanacz, László Buday   +12 more
doaj   +1 more source

Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro [PDF]

, 2018
Brown and beige adipocytes are characterised as expressing the unique mitochondrial uncoupling protein (UCP)1 for which the primary stimulus in vivo is cold exposure.
A Bartelt, A Krings, A Mostyn, A Mostyn, A Park, A Suzuki, AC Bianco, AG Little, AI Caplan, AM Cypess, AS Borowiec, B Cannon, B Vagaska, C Pontikoglou, C Vogel, CA Schneider, CJ Villanueva, CN Miller, D Patsouris, D Vargas, DL Drehmer, E Lee, EC Cottrell, ID Bloor, J Himms-Hagen, J Ishibashi, J Wu, JM Gimble, JM Jong de, JN Smith, JS Flier, KA Virtanen, L Attig, L Guasti, L Ye, LA Jesus de, LJ Bukowiecki, LS Sidossis, LZ Sharp, M Klingenspor, M Maffei, M Rosenwald, ME Symonds, MP Mollica, N Ghilardi, N Petrovic, P Laharrague, P Puigserver, P Puigserver, R Cancello, RA Garcia, S Cinti, S Cinti, S Dessolin, S Ussar, SM Al-Shibli, V Rizzatti, W Wang, WD Marken Lichtenbelt van, XX Yu, Z Zhou   +60 more
core   +3 more sources

3D Culture in Functionalized FN‐Silk Networks Facilitate Proliferation, Differentiation and Phenotypic Stability of Mature Human Primary Cells and Stem Cells

Biotechnology and Bioengineering, Volume 122, Issue 9, Page 2522-2534, September 2025.
The authors present a new technique for 3D culture of mammalian cells with the support of a microfiber‐based network of fibronectin (FN)‐functionalized recombinant silk. This feasible 2‐step method results in highly viable free‐floating 3D cultures with tissue‐mimicking morphology.
Astrid Källén, Nayere Taebnia, Mona Widhe, Volker M. Lauschke, My Hedhammar   +4 more
wiley   +1 more source

Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes

Advanced Science, 2020
Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown.
Jin Li, Xiaohan Pan, Guihua Pan, Zijun Song, Yao He, Susu Zhang, Xueru Ye, Xiang Yang, Enjun Xie, Xinhui Wang, Xudong Mai, Xiangju Yin, Biyao Tang, Xuan Shu, Pengyu Chen, Xiaoshuang Dai, Ye Tian, Liheng Yao, Mulan Han, Guohuan Xu, Huijie Zhang, Jia Sun, Hong Chen, Fudi Wang, Junxia Min, Liwei Xie   +25 more
doaj   +1 more source

Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy [PDF]

, 2014
miRNAs are important regulators of biological processes in many tissues, including the differentiation and function of brown and white adipocytes. the endoribonuclease dicer is a major component of the miRNA-processing pathway, and in adipose tissue ...
Aaron M. Cypess, C. Ronald Kahn, Hannele Yki-Järvinen, Himms-Hagen, Jason K. Kim, Jeremie Boucher, Kevin Y. Lee, Marcelo A. Mori, Martin Torriani, Pivonello, Steven K. Grinspoon, Susanna Lallukka, Thomas Thomou   +12 more
core   +1 more source

Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity

The Journal of Clinical Investigation
Type 2 innate lymphoid cells (ILC2s) regulate the proliferation of preadipocytes that give rise to beige adipocytes. Whether and how ILC2 downstream Th2 cytokines control beige adipogenesis remain unclear.
Alexandra R. Yesian, Mayer M. Chalom, Nelson H. Knudsen, Alec L. Hyde, Jean Personnaz, Hyunjii Cho, Yae-Huei Liou, Kyle A. Starost, Chia-Wei Lee, Dong-Yan Tsai, Hsing-Wei Ho, Jr-Shiuan Lin, Jun Li, Frank B. Hu, Alexander S. Banks, Chih-Hao Lee   +15 more
doaj   +1 more source

M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1

Nature Communications
Adipose tissue macrophages can promote beige adipose thermogenesis by altering local sympathetic activity. Here, we perform sympathectomy in mice and further eradicate subcutaneous adipose macrophages and discover that these macrophages have a direct ...
Suyang Wu, Chen Qiu, Jiahao Ni, Wenli Guo, Jiyuan Song, Xingyin Yang, Yulin Sun, Yanjun Chen, Yunxia Zhu, Xiaoai Chang, Peng Sun, Chunxia Wang, Kai Li, Xiao Han   +13 more
doaj   +1 more source