Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition [PDF]
Biology of Sex Differences, 2022 Highlights 1. Androgen excess in PCOS model is associated with decreased markers of mitochondrial content in both subcutaneous and visceral white adipose tissue. 2.
Jacob E. Pruett +9 more
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AdipoAtlas: A reference lipidome for human white adipose tissue
Cell Reports Medicine, 2021 Summary: Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders.
Mike Lange +6 more
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White Adipose Tissue in Obesity-Associated HFpEF [PDF]
JACC: Basic to Translational ScienceSummary: Obesity and hypertension are prevalent comorbidities in heart failure with preserved ejection fraction (HFpEF). Increased adiposity is implicated in its pathophysiology. We investigated changes in white adipose tissue (WAT) in obesity-associated
María Valero-Muñoz, PhD +4 more
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White adipose tissue uptake on 18F FDG PET/CT: A case report
Radiology Case ReportsThree distinct types of adipose tissue have been characterized: brown, white, and beige. Brown adipose tissue (BAT) is typically found in specific regions including the anterior cervical, supraclavicular, axillary, and paravertebral areas.
Maria Andrea Parra Corral, MD +1 more
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Nutrition & Metabolism, 2022 Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining health and homeostasis. Although white adipose tissue and brown adipose tissue are currently considered key endocrine organs, they differ functionally and ...
Sabrina Azevedo Machado +6 more
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Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism
Scientific Data, 2023 The prevalence of obesity and overweight is steadily rising, posing a significant global challenge for humanity. The fundamental cause of obesity and overweight lies in the abnormal accumulation of adipose tissue.
Tianci Liao +6 more
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Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]
, 2017 BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P +11 more
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Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue
Frontiers in Endocrinology, 2020 Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation.
Sebastian Dieckmann +14 more
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Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice
Biomedicines, 2022 Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE3) that increases intracellular cyclic adenosine monophosphate (cAMP), which plays a critical role in the development of the beige phenotype and the activation of its thermogenic program
Da Hea Seo +6 more
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The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least [PDF]
Endocrinology and Metabolism, 2023 The growing recognition of mitochondria’s crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for
Juan Cai, Fenfen Wang, Mengle Shao
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