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Frontiers in Endocrinology, 2023 Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu +7 more
doaj +3 more sources
Invited review: Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]
Animal, 2016 Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of factors called adipokines that are involved in a wide range of physiological and metabolic functions.
I. Louveau +3 more
doaj +4 more sources
Adipocyte, 2012 Obesity is currently a global pandemic, and is associated with increased mortality and co-morbidities including many metabolic diseases. Obesity is characterized by an increase in adipose mass due to increased energy intake, decreased energy expenditure,
Kristy L Townsend, Yu-Hua Tseng
exaly +3 more sources
Assessment of brown adipose tissue function
Frontiers in Physiology, 2013 In this review we discuss practical considerations for the assessment of brown adipose tissue in rodent models, focusing on mice. The central aim of the review is to provide a critical appraisal of the utility of specialised techniques for assessing ...
Samuel eVirtue +2 more
doaj +3 more sources
SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue [PDF]
Nature CommunicationsBrown adipose tissue is an evolutionary innovation in placental mammals that regulates body temperature through adaptive thermogenesis. Cold exposure activates brown adipose tissue thermogenesis through coordinated induction of brown adipogenesis ...
Tamires Duarte Afonso Serdan +15 more
doaj +2 more sources
The dorsal aortic compartment is a developmental source of brown adipose tissue in mice [PDF]
Nature CommunicationsWhite adipose tissue primarily stores energy while brown adipose tissue dissipates energy as heat, holding promise for therapeutic use. Brown adipose tissue in the anterior trunk is believed to derive from the somitic mesoderm, although some depots are ...
Sophie Heider +11 more
doaj +2 more sources
White and brown adipose tissue share a convergent fibro-adipogenic progenitor population [PDF]
EMBO ReportsAdipose tissue heterogeneity has emerged as a central factor in regulating adipose tissue function in physiology and pathophysiology, yet tools to model and study this diversity in vitro remain limited.
Hoang V Bui +3 more
doaj +2 more sources
Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue
Frontiers in Endocrinology, 2020 Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation.
Sebastian Dieckmann +14 more
doaj +1 more source
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]
, 2017 BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P +11 more
core +7 more sources
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit [PDF]
, 2013 Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue.
Chen, Y. +6 more
core +1 more source