Results 11 to 20 of about 3,183,818 (254)

Assessment of brown adipose tissue function

Frontiers in Physiology, 2013
In this review we discuss practical considerations for the assessment of brown adipose tissue in rodent models, focusing on mice. The central aim of the review is to provide a critical appraisal of the utility of specialised techniques for assessing ...
Samuel eVirtue, Antonio eVidal-Puig, Antonio eVidal-Puig   +2 more
doaj   +2 more sources

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue [PDF]

Nature Communications
Brown adipose tissue is an evolutionary innovation in placental mammals that regulates body temperature through adaptive thermogenesis. Cold exposure activates brown adipose tissue thermogenesis through coordinated induction of brown adipogenesis ...
Tamires Duarte Afonso Serdan, Heidi Cervantes, Benjamin Frank, Akhil Gargey Iragavarapu, Qiyu Tian, Daniel Hope, Chan Hee J. Choi, Anne Hoffmann, Adhideb Ghosh, Christian Wolfrum, Matthew B. Greenblatt, Paul Cohen, Matthias Blüher, Halil Aydin, Gary J. Schwartz, Farnaz Shamsi   +15 more
doaj   +2 more sources

BATLAS: Deconvoluting Brown Adipose Tissue [PDF]

Cell Reports, 2018
Summary: Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies ...
Aliki Perdikari, Germán Gastón Leparc, Miroslav Balaz, Nuno D. Pires, Martin E. Lidell, Wenfei Sun, Francesc Fernandez-Albert, Sebastian Müller, Nassila Akchiche, Hua Dong, Lucia Balazova, Lennart Opitz, Eva Röder, Holger Klein, Patrik Stefanicka, Lukas Varga, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Markku Taittonen, Gottfried Rudofsky, Jozef Ukropec, Sven Enerbäck, Elia Stupka, Heike Neubauer, Christian Wolfrum   +25 more
doaj   +4 more sources

Mitochondria-derived vesicles with bioenergetic units from brown adipose tissue attenuate cardiac remodeling post-myocardial infarction [PDF]

Nature Communications
Post-myocardial infarction remodeling is a major cause of heart failure, with contributions from multiple organs. Brown adipose tissue protects against cardiovascular disease, but the mediators of brown adipose tissue-heart crosstalk and their roles in ...
Tingting Shi, Feng Chen, Yue Xu, Kai Jiang, Ruhua Deng, Xingbo Yang, Yang Chen, Wenliang Che, John Hwa, Dandan Wang, Yaozu Xiang   +10 more
doaj   +2 more sources

The dorsal aortic compartment is a developmental source of brown adipose tissue in mice [PDF]

Nature Communications
White adipose tissue primarily stores energy while brown adipose tissue dissipates energy as heat, holding promise for therapeutic use. Brown adipose tissue in the anterior trunk is believed to derive from the somitic mesoderm, although some depots are ...
Sophie Heider, Cornelius Fischer, Ali Kerim Secener, Pedro Vallecillo-Garcı́a, Georgios Kotsaris, Zarah G. Meisen, Verena Pawolski, Claudia Giesecke-Thiel, Thomas Conrad, Tim J. Schulz, Sascha Sauer, Sigmar Stricker   +11 more
doaj   +2 more sources

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Frontiers in Endocrinology, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu, Xiaomeng Liu, Zhi Zhang, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong, Meng Dong   +7 more
doaj   +1 more source

Studies of adipose tissue in humans with special reference to innervation by the sympathetic nervous system [PDF]

, 2009
PhDThis thesis reports the effects in vivo of the sympathetic nervous system (SNS) in human subcutaneous abdominal white adipose tissue (WAT) and other tissues involved in energy storage and utilisation. Cannulation of superficial veins draining skin,
Lawence, Victor
core   +4 more sources

Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue

Frontiers in Endocrinology, 2020
Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation.
Sebastian Dieckmann, Sebastian Dieckmann, Sebastian Dieckmann, Stefanie Maurer, Stefanie Maurer, Stefanie Maurer, Tobias Fromme, Tobias Fromme, Tobias Fromme, Cécilia Colson, Kirsi A. Virtanen, Ez-Zoubir Amri, Martin Klingenspor, Martin Klingenspor, Martin Klingenspor   +14 more
doaj   +1 more source

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]

, 2016
Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Handschin, Christoph, Mitsugu Shimobayashi, Svensson, Kristoffer, Shimobayashi, Mitsugu, Muñoz, Sergio, Hall, Michael N., Verena Albert, Michael N Hall, Fatima Bosch, Albert, Verena, Kristoffer Svensson, Sergio Muñoz, Christoph Handschin, Bosch i Tubert, Fàtima, Colombi, Marco, Marco Colombi, Bosch, Fatima, Veronica Jimenez, Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG), Muñoz-Martínez, S, Jimenez, Veronica   +20 more
core   +1 more source

The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity

Nature Communications, 2020
Brown adipose tissue, known produce heat by metabolizing fat, is also secretes molecules capable of communicating with other organs. Here the authors show that brown adipose tissue secretes kininogen, a component of heat system regulation, that provides ...
Marion Peyrou, Rubén Cereijo, Tania Quesada-López, Laura Campderrós, Aleix Gavaldà-Navarro, Laura Liñares-Pose, Elena Kaschina, Thomas Unger, Miguel López, Marta Giralt, Francesc Villarroya   +10 more
doaj   +1 more source