BATLAS: Deconvoluting Brown Adipose Tissue [PDF]
Summary: Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies ...
Aliki Perdikari +25 more
doaj +5 more sources
Brown Adipose Tissue Growth and Development [PDF]
Brown adipose tissue is uniquely able to rapidly produce large amounts of heat through activation of uncoupling protein (UCP) 1. Maximally stimulated brown fat can produce 300 watts/kg of heat compared to 1 watt/kg in all other tissues.
Michael E. Symonds
doaj +2 more sources
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]
Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Handschin, Christoph +20 more
core +1 more source
The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity
Brown adipose tissue, known produce heat by metabolizing fat, is also secretes molecules capable of communicating with other organs. Here the authors show that brown adipose tissue secretes kininogen, a component of heat system regulation, that provides ...
Marion Peyrou +10 more
doaj +1 more source
Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats [PDF]
Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight loss.
Bidlingmaier, Martin +54 more
core +1 more source
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine [PDF]
Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis.
Christian, Mark, Christian, M
core +1 more source
Lipoprotein lipase (LPL) supplies brown adipose tissue with fatty acids for nonshivering thermogenesis. In brown adipose tissue of the Djungarian hamster we studied i) the molecular mechanisms involved in cold-induced stimulation of LPL activity, ii) the
M Klingenspor +6 more
doaj +1 more source
RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]
Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry +25 more
core +1 more source
Brown adipose tissue monocytes support tissue expansion
Adipose tissue is composed of a number of adipocytes and a number of other cells including immune cells. Here the authors use single-cell sequencing of murine brown adipose tissue immune cells and describe multiple macrophage and monocyte subsets and ...
Alexandre Gallerand +26 more
doaj +1 more source
Brown Adipose Tissue in a Newborn [PDF]
A premature infant boy of 35 weeks and 4 days weighing 2605 g was found to have bilateral supraclavicular masses at 13 days of life. He had persistent pulmonary hypertension of the newborn and thrombocytopenia. Delivery was by cesarean section for nonreassuring fetal status, and Apgar scores were 5 at 1 minute and 8 at 5 minutes. Initial radiographs
Brett W, Carter, William G, Schucany
openaire +2 more sources

