Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase [PDF]
Cell Reports, 2018 Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved.
David Lasar +18 more
doaj +10 more sources
Molecular Metabolism, 2019 Objective: Increasing the amounts of functionally competent brown adipose tissue (BAT) in adult humans has the potential to restore dysfunctional metabolism and counteract obesity.
Naja Z. Jespersen +15 more
doaj +3 more sources
E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat [PDF]
EMBO ReportsThermogenic fat, including brown and beige fat, dissipates heat via thermogenesis and enhances energy expenditure. Thus, its activation represents a therapeutic strategy to combat obesity.
Jian Yu +24 more
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Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice
Biomolecules, 2021 Increasing energy expenditure through activation of brown fat thermogenesis is a promising therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key player in regulating brown fat development and thermogenic program ...
Shirong Wang +7 more
doaj +1 more source
Brown Fat Dnmt3b Deficiency Ameliorates Obesity in Female Mice
Life, 2021 Obesity results from a chronic energy imbalance due to energy intake exceeding energy expenditure. Activation of brown fat thermogenesis has been shown to combat obesity. Epigenetic regulation, including DNA methylation, has emerged as a key regulator of
Fenfen Li +6 more
doaj +1 more source
Effect of Myostatin Gene Knockout on Browning of White Fat and Related Gene Expression Levels in a Mouse Model of Type 2 Diabetes Mellitus [PDF]
Zhongguo quanke yixue, 2022 Background The browning of white fat is a hot spot in metabolic disease research. Myostatin (Mstn) inhibits muscle growth, and has correlation with the growth and differentiation of adipocytes, but its effect on the browning of white fat in type 2 ...
Jingwei CHENG, Yangqing LIU, Yanfang WANG
doaj +1 more source
The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway. [PDF]
Exp Mol MedPark JY +8 more
europepmc +3 more sources
Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders [PDF]
Diabetes & Metabolism Journal, 2016 Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the ...
So Hun Kim, Jorge Plutzky
doaj +1 more source
Lipids in Health and Disease, 2020 Background Obesity is a metabolic imbalance characterized by excessive deposition of white fat. The browning of white fat can effectively treat obesity and related diseases.
Ju Zhang +8 more
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Temperature and species-dependent regulation of browning in retrobulbar fat
Scientific Reports, 2021 Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and transcriptionally resembles interscapular ...
Fatemeh Rajaii +6 more
doaj +1 more source