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E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat [PDF]
EMBO ReportsThermogenic fat, including brown and beige fat, dissipates heat via thermogenesis and enhances energy expenditure. Thus, its activation represents a therapeutic strategy to combat obesity.
Jian Yu +24 more
doaj +6 more sources
Brown Fat Dnmt3b Deficiency Ameliorates Obesity in Female Mice [PDF]
Life, 2021 Obesity results from a chronic energy imbalance due to energy intake exceeding energy expenditure. Activation of brown fat thermogenesis has been shown to combat obesity. Epigenetic regulation, including DNA methylation, has emerged as a key regulator of
Fenfen Li +6 more
doaj +2 more sources
Dietary Fat Overload Reprograms Brown Fat Mitochondria [PDF]
Frontiers in Physiology, 2015 Chronic nutrient overload accelerates the onset of several aging-related diseases reducing life expectancy. Although the mechanisms by which overnutrition affects metabolic processes in many tissues are known, its role on BAT physiology is still unclear.
DANIELE eLETTIERI BARBATO +6 more
doaj +4 more sources
Molecular Metabolism, 2019 Objective: Increasing the amounts of functionally competent brown adipose tissue (BAT) in adult humans has the potential to restore dysfunctional metabolism and counteract obesity.
Naja Z. Jespersen +15 more
doaj +3 more sources
3D brown adipogenesis to create “Brown-Fat-in-Microstrands” [PDF]
Biomaterials, 2016 The ability of brown adipocytes (fat cells) to dissipate energy as heat shows great promise for the treatment of obesity and other metabolic disorders. Employing pluripotent stem cells, with an emphasis on directed differentiation, may overcome many issues currently associated with primary fat cell cultures.
Yubing Xie, Yu-Hua Tseng
exaly +3 more sources
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice
Biomolecules, 2021 Increasing energy expenditure through activation of brown fat thermogenesis is a promising therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key player in regulating brown fat development and thermogenic program ...
Shirong Wang +7 more
doaj +1 more source
Effect of Myostatin Gene Knockout on Browning of White Fat and Related Gene Expression Levels in a Mouse Model of Type 2 Diabetes Mellitus [PDF]
Zhongguo quanke yixue, 2022 Background The browning of white fat is a hot spot in metabolic disease research. Myostatin (Mstn) inhibits muscle growth, and has correlation with the growth and differentiation of adipocytes, but its effect on the browning of white fat in type 2 ...
Jingwei CHENG, Yangqing LIU, Yanfang WANG
doaj +1 more source
Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders [PDF]
Diabetes & Metabolism Journal, 2016 Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the ...
So Hun Kim, Jorge Plutzky
doaj +1 more source
The Engineering of Brown Fat [PDF]
Journal of Molecular Cell Biology, 2009 The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPbeta, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.
Mark, Christian, Malcolm G, Parker
openaire +2 more sources
Annals of Medicine, 2014 Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and mitochondrial uncoupling in brown adipocytes.
Contreras, Cristina +6 more
openaire +5 more sources