Frontiers in Endocrinology, 2020 Brown adipose tissue from mice living under conditions approaching human thermal and nutritional conditions (prolonged exposure to thermoneutral temperature and to an energy-rich (high-fat, high-sugar) diet) — referred to as “physiologically humanized ...
Alexander W. Fischer +6 more
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Metabolic regulation and the anti-obesity perspectives of human brown fat
Redox Biology, 2017 Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity.
Camilla Scheele, Søren Nielsen
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DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice
Molecular Metabolism, 2023 Objectives: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth and metabolism. In mice, activation of mTOR controls cold adaptation by promoting the recruitment and the activation of brown adipose tissue (BAT ...
Charles Colas +6 more
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FAT-Richtlinie Dynamische Werkstoffkennwerte für die Crashsimulation
, 2022 Im Rahmen des AiF/FAT-Forschungsvorhabens 14205 ist die FAT-Richtline "Dynamische Werkstoffkennwerte für die Crashsimulation" (siehe [1]) zur zuverlässigen Bestimmung von crashrelevanten, dynamischen Werkstoffkennwerten für Crashsimulationen im ...
Blauel, J.G. +5 more
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TGF-beta/Smad3 signaling regulates brown adipocyte induction in white adipose tissue
Frontiers in Endocrinology, 2012 Recent identification of active brown fat reserves in adult humans has stimulated interest in the role of brown adipocytes in energy homeostasis. In addition, there is accumulating evidence to support the concept of an alteration in energy balance ...
Sushil G Rane, Hariom eYadav
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Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. [PDF]
PLoS ONE, 2009 BACKGROUND: Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white adipocytes are specialised in energy storage.
Maria Murholm +8 more
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Frontiers in Nutrition, 2022 Excess dietary fructose intake is a major public health concern due to its deleterious effect to cause various metabolic and cardiovascular diseases. However, little is known about the effects of high-fructose consumption during pregnancy on offspring ...
Peng Wang +8 more
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Derivation and characterization of a UCP1 reporter human ES cell line
Stem Cell Research, 2018 Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years.
Suranjit Mukherjee +6 more
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High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects [PDF]
, 2012 OBJECTIVE-To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state.
Varma, M.C. +23 more
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Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity.
PLoS ONE, 2012 Obesity is a major health problem worldwide. We are studying the causes and effects of obesity in C57Bl/6 mice following genetic ablation of NG2, a chondroitin sulfate proteoglycan widely expressed in progenitor cells and also in adipocytes.
Yunchao Chang +6 more
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