BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]
, 2019 Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow +72 more
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TGF-beta/Smad3 signaling regulates brown adipocyte induction in white adipose tissue
Frontiers in Endocrinology, 2012 Recent identification of active brown fat reserves in adult humans has stimulated interest in the role of brown adipocytes in energy homeostasis. In addition, there is accumulating evidence to support the concept of an alteration in energy balance ...
Sushil G Rane, Hariom eYadav
doaj +1 more source
Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. [PDF]
PLoS ONE, 2009 BACKGROUND: Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white adipocytes are specialised in energy storage.
Maria Murholm +8 more
doaj +1 more source
DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice
Molecular Metabolism, 2023 Objectives: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth and metabolism. In mice, activation of mTOR controls cold adaptation by promoting the recruitment and the activation of brown adipose tissue (BAT ...
Charles Colas +6 more
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Oxygen deprivation and the cellular response to hypoxia in adipocytes – perspectives on white and brown adipose tissues in obesity [PDF]
, 2015 Relative hypoxia has been shown to develop in white adipose tissue depots of different types of obese mouse (genetic, dietary), and this leads to substantial changes in white adipocyte function. These changes include increased production of inflammation-
Alomar, Suliman Yousef, Trayhurn, Paul
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Enhancing brown fat with NFIA [PDF]
Nature Cell Biology, 2017 Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
Suzanne N, Shapira, Patrick, Seale
openaire +2 more sources
Frontiers in Nutrition, 2022 Excess dietary fructose intake is a major public health concern due to its deleterious effect to cause various metabolic and cardiovascular diseases. However, little is known about the effects of high-fructose consumption during pregnancy on offspring ...
Peng Wang +8 more
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Impaired Thermogenesis and Adipose Tissue Development in Mice with Fat-Specific Disruption of Insulin and IGF-1 Signalling [PDF]
, 2012 Insulin and insulin-like growth factor 1 (IGF-1) play important roles in adipocyte differentiation, glucose tolerance and insulin sensitivity. Here, to assess how these pathways can compensate for each other, we created mice with a double tissue-specific
Bluher, Matthias +9 more
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Derivation and characterization of a UCP1 reporter human ES cell line
Stem Cell Research, 2018 Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years.
Suranjit Mukherjee +6 more
doaj +1 more source
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit [PDF]
, 2013 Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue.
Chen, Y. +6 more
core +1 more source