Yes, even human brown fat is on fire! [PDF]
, 2012 That adult humans possess brown fat is now accepted - but is the brown fat metabolically active? Does human brown fat actually combust fat to release heat? In this issue of the JCI, Ouellet et al.
Nedergaard, Jan, +6 more
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Brown Fat and Skeletal Muscle: Unlikely Cousins? [PDF]
, 2008 Although the functions of white fat and brown fat are increasingly well understood, their developmental origins remain unclear. A recent study published in Nature (Seale et al., 2008) identifies a population of progenitor cells that gives rise to brown ...
Farmer, Stephen R., Stephen R. Farmer
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Transcriptional control of brown fat determination by PRDM16. [PDF]
, 2007 International audienceBrown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown.
Rohas, Lindsay M. +10 more
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Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity.
PLoS ONE, 2012 Obesity is a major health problem worldwide. We are studying the causes and effects of obesity in C57Bl/6 mice following genetic ablation of NG2, a chondroitin sulfate proteoglycan widely expressed in progenitor cells and also in adipocytes.
Yunchao Chang +6 more
doaj +1 more source
Cell Reports, 2018 Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved.
David Lasar +18 more
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Inflammatory Signaling and Brown Fat Activity [PDF]
Frontiers in Endocrinology, 2020 Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in physiology and pathophysiology.
Omran, F, Christian, M
openaire +5 more sources
Indomethacin Enhances Brown Fat Activity [PDF]
, 2018 Indomethacin, a nonsteroidal anti-inflammatory drug, has been shown to induce white adipocyte differentiation; however, its roles in brown adipocyte differentiation and activation in brown adipose tissue (BAT) and obesity are unknown.
Hammock, Bruce D +21 more
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Baclofen is a potent activator of brown fat metabolism [PDF]
, 1985 The injection of (±)-baclofen intravenously or directly into the ventromedial hypothalamus of urethane-anaesthetized rats, produced an activation of brown fat metabolism.
Rothwell, N. J. +3 more
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Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity [PDF]
, 2016 Brown fat is a thermogenic tissue that generates heat to maintain body temperature in cold environments and dissipate excess energy in response to overfeeding. We have addressed the role of the IGFIR in the brown fat development and function.
García, Gema +6 more
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Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat [PDF]
, 2011 Peroxisome proliferator activated receptor α (PPARα) is a distinctive marker of the brown fat phenotype that has been proposed to coordinate the transcriptional activation of genes for lipid oxidation and for thermogenic uncoupling protein 1 in brown ...
Maria Monsalve +15 more
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