Results 31 to 40 of about 670,278 (352)

Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat [PDF]

, 2014
Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation1.
Cypess, Aaron M., Gussoni, Emanuela, Huang, Ping, Huang, Tian Lian, McDougall, Lindsay E., Mishina, Yuji, Schulz, Tim J., Townsend, Kristy L., Tseng, Yu-Hua, Xue, Ruidan   +9 more
core   +1 more source

Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity.

PLoS ONE, 2012
Obesity is a major health problem worldwide. We are studying the causes and effects of obesity in C57Bl/6 mice following genetic ablation of NG2, a chondroitin sulfate proteoglycan widely expressed in progenitor cells and also in adipocytes.
Yunchao Chang, Zhi-Gang She, Kenji Sakimura, Amanda Roberts, Karolina Kucharova, David H Rowitch, William B Stallcup   +6 more
doaj   +1 more source

Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy [PDF]

, 2014
miRNAs are important regulators of biological processes in many tissues, including the differentiation and function of brown and white adipocytes. the endoribonuclease dicer is a major component of the miRNA-processing pathway, and in adipose tissue ...
Aaron M. Cypess, C. Ronald Kahn, Hannele Yki-Järvinen, Himms-Hagen, Jason K. Kim, Jeremie Boucher, Kevin Y. Lee, Marcelo A. Mori, Martin Torriani, Pivonello, Steven K. Grinspoon, Susanna Lallukka, Thomas Thomou   +12 more
core   +1 more source

miR-34a-/- mice are susceptible to diet-induced obesity [PDF]

, 2016
Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H., Caslake, Muriel, Collier, Andrew, Donnelly, Iona, Holmes, William, Kurowska-Stolarska, Mariola, Lavery, Christopher A., Miller, Ashley M.   +7 more
core   +1 more source

Icariin has the potential to induce the differentiation of bone marrow mesenchymal stem cells into brown fat cells via PDE5A inhibition

Heliyon, 2023
Background: Bone marrow mesenchymal stem cells (BMMSCs) possess the ability of adipogenic differentiation. Icariin (ICA) is a prenylated flavonol glycoside with diverse pharmacological activities and has been reported to promote osteogenic ...
Yao Lu, Xiangfeng Xu, Sitong Liu, Zhaozheng Wang, Kai Jiang, Juan Gu, Li Fang, Rong Shen   +7 more
doaj   +1 more source

Brown fat depots in adult humans remain static in their locations on PET/CT despite changes in seasonality [PDF]

, 2017
Active brown adipose tissue (BAT) in humans has been demonstrated through use of positron emission tomography with 2-deoxy-2-(fluorine-18) fluoro-D-glucose integrated with computed tomography (18F-FDG PET/CT) scans.
Adesanya, Oludolapo, Barber, T. M., Dimitriadis, Georgios K., Hutchinson, Charles E., Jones, Terence A., Reddy, Narendra Lakshmana, Wayte, Sarah   +6 more
core   +1 more source

Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity

Scientific Reports, 2022
Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%.
Mojgan Nazari, Kenneth W. Ho, Natasha Langley, Kuan M. Cha, Raymond Kodsi, Mawson Wang, D. Ross Laybutt, Kim Cheng, Rebecca A. Stokes, Michael M. Swarbrick, Jenny E. Gunton   +10 more
doaj   +1 more source

Peroxisome proliferator activated receptors-α and -Υ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue [PDF]

, 2012
Retinol binding protein-4 (RBP4) is a serum protein involved in the transport of vitamin A. It is known to be produced by the liver and white adipose tissue. RBP4 release by white fat has been proposed to induce insulin resistance.
Giralt, Marta, González, Frank J., Hondares, Elayne, Iglesias, Roser, Iwamoto, Sadahiko, Monsalve, María, Olmos, Yolanda, Rosell, Meritxell, Staels, Bart, Villarroya, Fransesc, Wabitsch, Martin   +10 more
core   +2 more sources

Role of energy metabolism in the brown fat gene program

Frontiers in Endocrinology, 2015
In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes.
Minwoo eNam, Marcus eCooper
doaj   +1 more source

Ontogeny and thermogenic role for sternal fat in female sheep [PDF]

, 2017
Brown adipose tissue acting through a unique uncoupling protein (UCP1) has a critical role in preventing hypothermia in new-born sheep but is then considered to rapidly disappear during postnatal life.
Albrecht, Alexander, Alexander, Atit, Bal, Barquissau, Basse, Belinda A. Henry, Bispham, Blessing, Blondin, Bloor, Cantile, Cao, Christian, Christodoulides, Clapham, Clarke, Clarke, Clarke, de Jong, Ellis, Elsen, Forner, Gburcik, Harms, Helen Budge, Henry, Henry, Henry, Henry, Horvath, Hotta, Hunt, Iain J. Clarke, John-Paul Fuller-Jackson, Kiskinis, Kooijman, Kurose, Lean, Lee, Lee, Loomis, Macotela, Mark Birtwistle, Mark Pope, Michael E. Symonds, Moldes, Møller, Nedergaard, Nedergaard, Nygaard, Ojha, Ootsuka, Petrovic, Pope, Rachael Loughnan, Ramayo-Caldas, Reham Alagal, Rosell, Rowland, Sacks, Sanchez-Gurmaches, Sanchez-Gurmaches, Scheele, Scotney, Seale, Sechen, Shan, Shinoda, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Timmons, van Marken Lichtenbelt, Vergnes, Virtanen, Viv Perry, Wellik, Xue, Yamamoto   +84 more
core   +2 more sources