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Physiological Reviews, 1969 Robert Emrie Smith and Barbara A. Horwitz, “Brown Fat and Thermogenesis” See PDF for Table
R E, Smith, B A, Horwitz
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Dietary Fat Overload Reprograms Brown Fat Mitochondria [PDF]
Frontiers in Physiology, 2015 Chronic nutrient overload accelerates the onset of several aging-related diseases reducing life expectancy. Although the mechanisms by which overnutrition affects metabolic processes in many tissues are known, its role on BAT physiology is still unclear.
DANIELE eLETTIERI BARBATO +6 more
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Canadian Journal of Biochemistry and Physiology, 1962 The lipids of the interscapular brown fat of the white mouse have been examined by means of silicic acid column chromatography and quantitative paper chromatography. The fatty acid composition of the glycerides and phosphatides was determined by gas chromatography.
W A, SPENCER, G, DEMPSTER
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Nature Medicine, 2015 Adipocyte progenitors have the capacity to differentiate into mature brown adipocytes with thermogenic capabilities. Two new studies identify novel markers to help prospectively isolate these and mature adipocytes from human brown fat biopsies.
Boon, M.R. +2 more
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Inflammatory Signaling and Brown Fat Activity [PDF]
Frontiers in Endocrinology, 2020 Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in ...
Farah Omran, Mark Christian
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Annals of Medicine, 2014 Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and mitochondrial uncoupling in brown adipocytes.
Contreras, Cristina +6 more
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The Engineering of Brown Fat [PDF]
Journal of Molecular Cell Biology, 2009 The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPbeta, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.
Mark, Christian, Malcolm G, Parker
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Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats [PDF]
, 2012 Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight loss.
Bidlingmaier, Martin +54 more
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RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]
, 2014 Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry +25 more
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Enhancing brown fat with NFIA [PDF]
Nature Cell Biology, 2017 Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
Suzanne N, Shapira, Patrick, Seale
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