Role of energy metabolism in the brown fat gene program [PDF]
Frontiers in Endocrinology, 2015 In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes.
Minwoo eNam, Marcus eCooper
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Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells [PDF]
Frontiers in Endocrinology, 2015 Brown adipocytes are a specialized cell type that is critical for adaptive thermogenesis, energy homeostasis and metabolism. In response to cold, both classical brown fat and the newly identified beige or brite cells are activated by β-adrenergic ...
Sean Bong Lee +2 more
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Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat [PDF]
Cell Reports, 2017 Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of
Lu Yao +8 more
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FAT TISSUE DISTRIBUTION BETWEEN SUBCUTANEOUS AND INTERMUSCULAR FAT TISSUE IN SIMMENTAL AND BROWN BULLS [PDF]
Poljoprivreda, 2007 Simmental and Brown bulls from progeny testing station were used to evaluate the effect of breed on fat tissue partition between subcutaneous and intermuscular fat.
S. Žgur, M. Čepon
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Genetic backgrounds determine brown remodeling of white fat in rodents [PDF]
Molecular Metabolism, 2016 Objective: Genetic background largely contributes to the complexity of metabolic responses and dysfunctions. Induction of brown adipose features in white fat, known as brown remodeling, has been appreciated as a promising strategy to offset the positive ...
Giulia Ferrannini +7 more
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Lipids in Health and Disease, 2020 Background Obesity is a metabolic imbalance characterized by excessive deposition of white fat. The browning of white fat can effectively treat obesity and related diseases.
Ju Zhang +8 more
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Temperature and species-dependent regulation of browning in retrobulbar fat
Scientific Reports, 2021 Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and transcriptionally resembles interscapular ...
Fatemeh Rajaii +6 more
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Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. [PDF]
PLoS ONE, 2012 Previous evidence indicates that duodenal lipid sensing engages gut-brain neurocircuits to determine food intake and hepatic glucose production, but a potential role for gut-brain communication in the control of energy expenditure remains to be ...
Clémence Blouet, Gary J Schwartz
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Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats [PDF]
, 2012 Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight loss.
Bidlingmaier, Martin +54 more
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RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]
, 2014 Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry +25 more
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