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Brown adipose tissue [PDF]

Adipocyte, 2012
Obesity is currently a global pandemic, and is associated with increased mortality and co-morbidities including many metabolic diseases. Obesity is characterized by an increase in adipose mass due to increased energy intake, decreased energy expenditure,
Kristy L Townsend, Yu-Hua Tseng
exaly   +8 more sources

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Frontiers in Endocrinology, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu, Zhi Zhang
exaly   +3 more sources

Invited review: Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]

Animal, 2016
Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of factors called adipokines that are involved in a wide range of physiological and metabolic functions.
I. Louveau, M.-H. Perruchot, M. Bonnet, F. Gondret   +3 more
doaj   +4 more sources

Assessment of brown adipose tissue function

Frontiers in Physiology, 2013
In this review we discuss practical considerations for the assessment of brown adipose tissue in rodent models, focusing on mice. The central aim of the review is to provide a critical appraisal of the utility of specialised techniques for assessing ...
SAm Virtue, Antonio Vidal-Puig
exaly   +3 more sources

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue [PDF]

Nature Communications
Brown adipose tissue is an evolutionary innovation in placental mammals that regulates body temperature through adaptive thermogenesis. Cold exposure activates brown adipose tissue thermogenesis through coordinated induction of brown adipogenesis ...
Tamires Duarte Afonso Serdan, Heidi Cervantes, Benjamin Frank, Akhil Gargey Iragavarapu, Qiyu Tian, Daniel Hope, Chan Hee J. Choi, Anne Hoffmann, Adhideb Ghosh, Christian Wolfrum, Matthew B. Greenblatt, Paul Cohen, Matthias Blüher, Halil Aydin, Gary J. Schwartz, Farnaz Shamsi   +15 more
doaj   +2 more sources

Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue

Frontiers in Endocrinology, 2020
Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation.
Sebastian Dieckmann, Sebastian Dieckmann, Sebastian Dieckmann, Stefanie Maurer, Stefanie Maurer, Stefanie Maurer, Tobias Fromme, Tobias Fromme, Tobias Fromme, Cécilia Colson, Kirsi A. Virtanen, Ez-Zoubir Amri, Martin Klingenspor, Martin Klingenspor, Martin Klingenspor   +14 more
doaj   +1 more source

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]

, 2017
BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P, Danai, Laura V, Guilherme, Adilson, Henchey, Elizabeth, Henriques, Felipe S, Jung, DaeYoung, Kim, Jason K, Lodhi, Irfan J, Pedersen, David J, Semenkovich, Clay F, Shen, Yuefei, Yenilmez, Batuhan   +11 more
core   +7 more sources

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit [PDF]

, 2013
Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue.
Chen, Y., Froehlich, H., Haas, B., Kipschull, S., Meister, G., Pfeifer, A., Siegel, F.   +6 more
core   +1 more source

The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity

Nature Communications, 2020
Brown adipose tissue, known produce heat by metabolizing fat, is also secretes molecules capable of communicating with other organs. Here the authors show that brown adipose tissue secretes kininogen, a component of heat system regulation, that provides ...
Marion Peyrou, Rubén Cereijo, Tania Quesada-López, Laura Campderrós, Aleix Gavaldà-Navarro, Laura Liñares-Pose, Elena Kaschina, Thomas Unger, Miguel López, Marta Giralt, Francesc Villarroya   +10 more
doaj   +1 more source

Intravitreally injected anti-VEGF antibody reduces brown fat in neonatal mice [PDF]

, 2015
Anti-vascular endothelial growth factor (VEGF) agents are the mainstay treatment for various angiogenesis-related retinal diseases. Currently, bevacizumab, a recombinant humanized anti-VEGF antibody, is trailed in retinopathy of prematurity, a ...
A Hellstrom, AL Hard, AM Cypess, B Cannon, BJ Lee, Chang Sik Cho, D Lepore, DF Martin, DH Jo, Dong Hyun Jo, H Kim, HA Mintz-Hittner, HA Mintz-Hittner, HK Sung, I Elias, I Shimizu, J Qian, Jeong Hun Kim, JH Kim, Jin Hyoung Kim, K Sun, L Sidossis, LA Kim, LE Smith, M Bagchi, M Tolentino, Marcus Fruttiger, Marià Alemany, MB Powner, Michael B. Powner, MO Stefanini, MS Gordon, P van Wijngaarden, RL Avery, RL Avery, Sung Wook Park, T Miyake, T Sato, WC Wu, Y Cao, Y Xue   +40 more
core   +7 more sources