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Frontiers in Endocrinology, 2023 Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu +7 more
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Assessment of brown adipose tissue function
Frontiers in Physiology, 2013 In this review we discuss practical considerations for the assessment of brown adipose tissue in rodent models, focusing on mice. The central aim of the review is to provide a critical appraisal of the utility of specialised techniques for assessing ...
Samuel eVirtue +2 more
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The dorsal aortic compartment is a developmental source of brown adipose tissue in mice [PDF]
Nature CommunicationsWhite adipose tissue primarily stores energy while brown adipose tissue dissipates energy as heat, holding promise for therapeutic use. Brown adipose tissue in the anterior trunk is believed to derive from the somitic mesoderm, although some depots are ...
Sophie Heider +11 more
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SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue [PDF]
Nature CommunicationsBrown adipose tissue is an evolutionary innovation in placental mammals that regulates body temperature through adaptive thermogenesis. Cold exposure activates brown adipose tissue thermogenesis through coordinated induction of brown adipogenesis ...
Tamires Duarte Afonso Serdan +15 more
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White and brown adipose tissue share a convergent fibro-adipogenic progenitor population [PDF]
EMBO ReportsAdipose tissue heterogeneity has emerged as a central factor in regulating adipose tissue function in physiology and pathophysiology, yet tools to model and study this diversity in vitro remain limited.
Hoang V Bui +3 more
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Renaissance of Brown Adipose Tissue [PDF]
Hormone Research in Paediatrics, 2011 The recent discovery of functional brown adipose tissue in human adults raised this tissue again into the focus of current investigations concerning human energy homeostasis. Brown fat is a key thermogenic tissue and is essential for non-shivering thermogenesis in the human newborn and hibernating mammals.
Tews, D., Wabitsch, M.
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Brown adipose tissue and bone [PDF]
International Journal of Obesity Supplements, 2015 Brown adipose tissue (BAT) is capable of transforming chemically stored energy, in the form of triglycerides, into heat. Recent studies have shown that metabolically active BAT is present in a large proportion of adult humans, where its activity correlates with a favorable metabolic status. Hence, the tissue is now regarded as an interesting target for
M E, Lidell, S, Enerbäck
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Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue
Frontiers in Endocrinology, 2020 Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation.
Sebastian Dieckmann +14 more
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Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning
International Journal of Molecular Sciences, 2022 The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans
Iker Gómez-García +4 more
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Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
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