An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin [PDF]
Frontiers in Endocrinology, 2023 Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity.
Khanyisani Ziqubu +9 more
doaj +4 more sources
Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions [PDF]
Journal of Tissue Engineering, 2022 Engineered beige adipose tissues could be used for screening therapeutic strategies or as a direct treatment for obesity and metabolic disease. Microvascular fragments are vessel structures that can be directly isolated from adipose tissue and may ...
Francisca M. Acosta +6 more
doaj +3 more sources
Brown and Beige Adipose Tissue and Aging [PDF]
Frontiers in Endocrinology, 2019 Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes dysfunctional with an increase in production of inflammatory peptides, a decline of those with anti-inflammatory activity and infiltration of macrophages.
Elena Zoico +7 more
doaj +4 more sources
Bioengineering beige adipose tissue therapeutics [PDF]
Frontiers in Endocrinology, 2015 Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue.
Kevin eTharp, Andreas eStahl
doaj +4 more sources
Brown and beige adipose tissue‐derived metabokine and lipokine inter‐organ signalling in health and disease [PDF]
Experimental PhysiologyAdipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipose tissue‐mediated autocrine, paracrine and endocrine ...
Anna Malicka +3 more
doaj +3 more sources
Maintaining mitochondria in beige adipose tissue [PDF]
Adipocyte, 2019 Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve ...
Xiaodan Lu
doaj +3 more sources
Engineering Human Beige Adipose Tissue [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 In this study, we described a method for generating functional, beige (thermogenic) adipose microtissues from human microvascular fragments (MVFs). The MVFs were isolated from adipose tissue acquired from adults over 50 years of age.
Maria A. Gonzalez Porras +7 more
doaj +2 more sources
Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis [PDF]
Frontiers in Physiology, 2021 Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park +5 more
doaj +2 more sources
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
Molecular Metabolism, 2016 Objective: The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals.
Rachel R. Stine +6 more
doaj +3 more sources
Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus [PDF]
Adipocyte, 2021 Long Cheng +2 more
exaly +2 more sources