Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
Сахарный диабет, 2014 According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered.
Ekaterina Olegovna Koksharova +3 more
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The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]
, 2007 During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
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Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone
Biology, 2019 While it is now understood that the proper expansion of adipose tissue is critically important for metabolic homeostasis, it is also appreciated that adipose tissues perform far more functions than simply maintaining energy balance.
Kevin J. Phillips
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RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]
, 2014 Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry +25 more
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Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold [PDF]
Scientific Reports, 2019 AbstractIn a recent study, repeated cold application induced beiging in subcutaneous white adipose tissue (SC WAT) of humans independent of body mass index. To identify factors that promote or inhibit beiging, we performed multiplex analysis of gene expression with the Nanostring nCounter system (the probe set contained genes for specific immune cell ...
Brian S. Finlin +9 more
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mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]
, 2016 Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Handschin, Christoph +20 more
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The role of brown and beige adipose tissue in glycaemic control
Molecular Aspects of Medicine, 2019 For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting the so-called batokines to ...
Klepac, K. +3 more
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Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations [PDF]
Diabetes, 2015 Regular physical activity and exercise training have long been known to cause adaptations to white adipose tissue (WAT), including decreases in cell size and lipid content and increases in mitochondrial proteins. In this article, we discuss recent studies that have investigated the effects of exercise training on mitochondrial function, the “beiging ...
Stanford, Kristin I. +2 more
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Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
Cell Reports, 2018 Summary: Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity.
Xing Zhang +16 more
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Beta‐adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue
Physiological Reports, 2023 Activation of thermogenic adipose tissue depots has been linked to improved metabolism and weight loss. To study the molecular regulation of adipocyte thermogenesis, we performed RNA‐Seq on brown adipose tissue (BAT), gonadal white adipose tissue (gWAT),
Henry A. Paz +5 more
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