Results 31 to 40 of about 1,797,962 (199)

Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism

JCI Insight, 2021
BACKGROUND Beige and brown adipose tissue (BAT) are associated with improved metabolic homeostasis. We recently reported that the β3-adrenergic receptor agonist mirabegron induced beige adipose tissue in obese insulin-resistant subjects, and this was ...
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern   +12 more
doaj   +1 more source

MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Objective: Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control of this network by microRNAs remains incompletely understood.
Milessa Silva Afonso, Narendra Verma, Coen van Solingen, Yannick Cyr, Monika Sharma, Luce Perie, Emma M. Corr, Martin Schlegel, Lianne C. Shanley, Daniel Peled, Jenny Y. Yoo, Ann Marie Schmidt, Elisabetta Mueller, Kathryn J. Moore   +13 more
openaire   +2 more sources

FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue [PDF]

SSRN Electronic Journal, 2021
Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import.
Zhang, Yingyi, Hao, Jielu, Tarrago, Mariana G., Warner, Gina M., Giorgadze, Nino, Wei, Qing, Huang, Yan, He, Kai, Chen, Chuan, Peclat, Thais R., White, Thomas A., Ling, Kun, Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N., Hu, Jinghua   +15 more
openaire   +2 more sources

Brown and Beige Fat: Therapeutic Potential in Obesity

Indonesian Biomedical Journal, 2014
BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj   +1 more source

Thermogenic adipose tissue aging: Mechanisms and implications

Frontiers in Cell and Developmental Biology, 2022
Adipose tissue undergoes significant anatomical and functional changes with aging, leading to an increased risk of metabolic diseases. Age-related changes in adipose tissue include overall defective adipogenesis, dysfunctional adipokine secretion ...
Graciano da Nadyellem Silva, Angelica Amorim Amato   +1 more
doaj   +1 more source

Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes. [PDF]

J Physiol Biochem, 2019
Mammalian adipose tissue is traditionally categorized into white and brown relating to their function and morphology: while white serves as an energy storage, brown adipose tissue acts as the heat generator maintaining the core body temperature. The most
Kaisanlahti A, Glumoff T.
europepmc   +2 more sources

TGF-β receptor 1 regulates progenitors that promote browning of white fat

Molecular Metabolism, 2018
Objective: Beige/brite adipose tissue displays morphological characteristics and beneficial metabolic traits of brown adipose tissue. Previously, we showed that TGF-β signaling regulates the browning of white adipose tissue. Here, we inquired whether TGF-
Umesh D. Wankhade, Ji-Hyeon Lee, Pradeep K. Dagur, Hariom Yadav, Michael Shen, Weiping Chen, Ashok B. Kulkarni, J. Philip McCoy, Toren Finkel, Aaron M. Cypess, Sushil G. Rane   +10 more
doaj   +1 more source

The Gq signalling pathway inhibits brown and beige adipose tissue. [PDF]

Nat Commun, 2016
AbstractBrown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the GPCRs link to the Gq family, and inhibition of
Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A.   +18 more
europepmc   +7 more sources

Ceiling culture of human mature white adipocytes with a browning agent: A novel approach to induce transdifferentiation into beige adipocytes

Frontiers in Bioengineering and Biotechnology, 2022
Excess and dysfunctional adipose tissue plays an important role in metabolic diseases, including obesity, atherosclerosis and type 2 diabetes mellitus. In mammals, adipose tissue is categorized into two types: white and brown.
Yufei He, Zhuokai Liang, Jing Wang, Haojing Tang, Jian Li, Junrong Cai, Yunjun Liao   +6 more
doaj   +1 more source

The great roundleaf bat (Hipposideros armiger) as a good model for cold-induced browning of intra-abdominal white adipose tissue. [PDF]

PLoS ONE, 2014
Inducing beige fat from white adipose tissue (WAT) is considered to be a shortcut to weight loss and increasingly becoming a key area in research into treatments for obesity and related diseases.
Yao Wang, Tengteng Zhu, Shanshan Ke, Na Fang, David M Irwin, Ming Lei, Junpeng Zhang, Huizhen Shi, Shuyi Zhang, Zhe Wang   +9 more
doaj   +1 more source