Results 31 to 40 of about 9,335 (162)

The great roundleaf bat (Hipposideros armiger) as a good model for cold-induced browning of intra-abdominal white adipose tissue. [PDF]

PLoS ONE, 2014
Inducing beige fat from white adipose tissue (WAT) is considered to be a shortcut to weight loss and increasingly becoming a key area in research into treatments for obesity and related diseases.
Yao Wang, Tengteng Zhu, Shanshan Ke, Na Fang, David M Irwin, Ming Lei, Junpeng Zhang, Huizhen Shi, Shuyi Zhang, Zhe Wang   +9 more
doaj   +1 more source

Ceiling culture of human mature white adipocytes with a browning agent: A novel approach to induce transdifferentiation into beige adipocytes

Frontiers in Bioengineering and Biotechnology, 2022
Excess and dysfunctional adipose tissue plays an important role in metabolic diseases, including obesity, atherosclerosis and type 2 diabetes mellitus. In mammals, adipose tissue is categorized into two types: white and brown.
Yufei He, Zhuokai Liang, Jing Wang, Haojing Tang, Jian Li, Junrong Cai, Yunjun Liao   +6 more
doaj   +1 more source

FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue [PDF]

SSRN Electronic Journal, 2021
Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import.
Zhang, Yingyi, Hao, Jielu, Tarrago, Mariana G., Warner, Gina M., Giorgadze, Nino, Wei, Qing, Huang, Yan, He, Kai, Chen, Chuan, Peclat, Thais R., White, Thomas A., Ling, Kun, Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N., Hu, Jinghua   +15 more
openaire   +2 more sources

Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues

Сахарный диабет, 2014
According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered.
Ekaterina Olegovna Koksharova, Alexander Yur'evich Mayorov, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov   +3 more
doaj   +1 more source

Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone

Biology, 2019
While it is now understood that the proper expansion of adipose tissue is critically important for metabolic homeostasis, it is also appreciated that adipose tissues perform far more functions than simply maintaining energy balance.
Kevin J. Phillips
doaj   +1 more source

Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold [PDF]

Scientific Reports, 2019
AbstractIn a recent study, repeated cold application induced beiging in subcutaneous white adipose tissue (SC WAT) of humans independent of body mass index. To identify factors that promote or inhibit beiging, we performed multiplex analysis of gene expression with the Nanostring nCounter system (the probe set contained genes for specific immune cell ...
Brian S. Finlin, Amy L. Confides, Beibei Zhu, Mary C. Boulanger, Hasiyet Memetimin, Kyle W. Taylor, Zachary R. Johnson, Philip M. Westgate, Esther E. Dupont-Versteegden, Philip A. Kern   +9 more
openaire   +2 more sources

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations [PDF]

Diabetes, 2015
Regular physical activity and exercise training have long been known to cause adaptations to white adipose tissue (WAT), including decreases in cell size and lipid content and increases in mitochondrial proteins. In this article, we discuss recent studies that have investigated the effects of exercise training on mitochondrial function, the “beiging ...
Stanford, Kristin I., Middelbeek, Roeland J.W., Goodyear, Laurie J.   +2 more
openaire   +2 more sources

Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway

Cell Reports, 2018
Summary: Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity.
Xing Zhang, Yan Luo, Chunqing Wang, Xiaofeng Ding, Xin Yang, Dandan Wu, Floyd Silva, Zijiang Yang, Qin Zhou, Lu Wang, Xiaoqing Wang, Jianlin Zhou, Nathan Boyd, Michael Spafford, Mark Burge, Xuexian O. Yang, Meilian Liu   +16 more
doaj   +1 more source

Beta‐adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue

Physiological Reports, 2023
Activation of thermogenic adipose tissue depots has been linked to improved metabolism and weight loss. To study the molecular regulation of adipocyte thermogenesis, we performed RNA‐Seq on brown adipose tissue (BAT), gonadal white adipose tissue (gWAT),
Henry A. Paz, Anna‐Claire Pilkington, Hannah D. Loy, Ying Zhong, Kartik Shankar, Umesh D. Wankhade   +5 more
doaj   +1 more source

Brown and beige adipose tissues

Journal of Applied Physiology, 2018
With the recent rediscovery of brown fat in adult humans, our outlook on adipose tissue biology has undergone a paradigm shift. While we attempt to identify, recruit, and activate classic brown fat stores in humans, identification of beige fat has also raised the possibility of browning our white fat stores.
Chechi, Kanta, van Marken Lichtenbelt, Wouter, Richard, Denis   +2 more
openaire   +1 more source