Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: White adipocytes store lipids, have a large lipid droplet and few mitochondria. Brown and beige adipocytes, which produce heat, are characterized by high expression of uncoupling protein (UCP) 1, multilocular lipid droplets, and large ...
Rini Arianti +2 more
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Ceiling culture of human mature white adipocytes with a browning agent: A novel approach to induce transdifferentiation into beige adipocytes [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Excess and dysfunctional adipose tissue plays an important role in metabolic diseases, including obesity, atherosclerosis and type 2 diabetes mellitus. In mammals, adipose tissue is categorized into two types: white and brown.
Junrong Cai, He Yufei
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UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes [PDF]
Frontiers in Endocrinology, 2020 Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient ...
Yamada Tetsuya, Ikeda Kenji
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Functional and Genetic Characterization of Porcine Beige Adipocytes [PDF]
Cells, 2022 Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained substantial attention as an alternative cellular anti-obesity target in humans.
Lilan Zhang +9 more
doaj +2 more sources
LSD1 in beige adipocytes protects cardiomyocytes against oxygen and glucose deprivation [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Epicardial adipose tissue (EpAT) is known for its role in supporting the cardiomyocytes. Lysine-specific demethylase 1 (LSD1), a typical lysine demethylase, is an essential regulator for the maintenance of beige adipocytes.
Yiqiu Cao +3 more
doaj +2 more sources
Rutin Maintains the Thermogenic Phenotype of Beige Adipocytes and Concomitantly Suppresses Mitophagy Against Obesity in HFD Mice [PDF]
MetabolitesBackground: The browning of white adipose tissue for thermogenesis is an effective strategy for combating obesity. The formation of beige adipocytes is reversible, making their maintenance a key therapeutic target.
Jianmei Li +5 more
doaj +2 more sources
Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo
Pharmaceuticals, 2022 Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Zoltan Balajthy +2 more
exaly +3 more sources
Cell Reports, 2018 Summary: Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making ...
Julieta Martino +2 more
exaly +3 more sources
Nicotinamide-riboside shifts the differentiation of human primary white adipocytes to beige adipocytes impacting substrate preference and uncoupling respiration through SIRT1 activation and mitochondria-derived reactive species production [PDF]
Frontiers in Cell and Developmental Biology, 2022 Beige adipocytes play key roles in organismal energy and metabolic balance. In this study, we assessed whether the supplementation of human white adipocytes, differentiated from human adipose tissue-derived stem cells, with nicotinamide riboside (NR), a ...
Lilla Nagy +10 more
doaj +2 more sources
Human beige adipocytes for drug discovery and cell therapy in metabolic diseases [PDF]
Nature Communications, 2020 Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic ...
Amar M. Singh +9 more
doaj +2 more sources