Results 41 to 50 of about 8,254 (159)
Nicotine induces a dual effect on the beige-like phenotype in adipocytes [PDF]
Archives of Biological Sciences, 2019 Nicotine, the main component of cigarette smoke, affects white/brown adipocytes. Few studies have concentrated on beige adipocytes. In this study, 3T3-L1 cells were differentiated in the presence of nicotine (25, 50 and 100 μmol/L) during early ...
Chen Hui-Jian +5 more
doaj +1 more source
Advanced Science, 2023 N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li +16 more
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Beige adipocytes contribute to breast cancer progression
Oncology Reports, 2020 Adipocytes are the main stromal cells in the mammary microenvironment, and crosstalk between adipocytes and breast cancer cells may play a critical and important role in cancer maintenance and progression. Tumor‑induced differentiation to beige/brown adipose tissue is an important contribution to the hypermetabolic state of breast cancer.
Gantov, Mariana +6 more
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A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
Cell Reports, 2020 Summary: UCP1-dependent thermogenesis is studied to define new strategies to ameliorate obesity and type 2 diabetes; however, animal models are mostly limited to germline mutations of UCP1, which can effect adaptive changes in UCP1-independent pathways ...
Tenagne D. Challa +7 more
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eLife, 2017 Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic ...
Yuwei Jiang +2 more
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Formation of thermogenic adipocytes: What we have learned from pigs
Fundamental Research, 2021 Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise.
Jianguo Zhao +4 more
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Frontiers in EndocrinologyBackgroundThermogenic beige adipocytes, which dissipate energy as heat, are found in neonates and adults. Recent studies show that neonatal beige adipocytes are highly plastic and contribute to >50% of beige adipocytes in adults.
Raja Gopal Reddy Mooli +12 more
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PCB126 blocks the thermogenic beiging response of adipocytes
Environmental Science and Pollution Research, 2019 Subcutaneous white adipose tissue is capable of becoming thermogenic in a process that is referred to as "beiging." Beiging is associated with activation of the uncoupling protein, UCP1, and is known to be important for preventing adipose hypertrophy and development of insulin resistance.
Francoise A. Gourronc +3 more
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TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis [PDF]
Nature Communications, 2020 AbstractIt has been suggested that beige fat thermogenesis is tightly controlled by epigenetic regulators that sense environmental cues such as temperature. Here, we report that subcutaneous adipose expression of the DNA demethylase TET1 is suppressed by cold and other stimulators of beige adipocyte thermogenesis.
Sneha Damal Villivalam +8 more
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Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone
Biology, 2019 While it is now understood that the proper expansion of adipose tissue is critically important for metabolic homeostasis, it is also appreciated that adipose tissues perform far more functions than simply maintaining energy balance.
Kevin J. Phillips
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