Results 41 to 50 of about 59,004 (177)

Thermogenic adipose tissue in energy regulation and metabolic health

Frontiers in Endocrinology, 2023
The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat cells that regulate energy balance. Both adipocytes share common morphological,
Siwen Xue, Derek Lee, Daniel C. Berry
doaj   +1 more source

Chrna2-driven CRE Is Expressed in Beige Adipocytes.

Endocrinology
Abstract Significant research interest has been focused on beige adipocytes, the activation of which improves glucose and lipid homeostasis, therefore representing new therapeutic opportunities for metabolic diseases. Various Cre/Lox-based strategies have been used to investigate the developmental history of beige adipocytes and how ...
Zhu K, Liu S, Huang Y, Zhang B, Houssein N, Wu J.   +5 more
europepmc   +3 more sources

Adaptive thermogenesis in adipocytes: Is beige the new brown? [PDF]

Genes & Development, 2013
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat.
Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.   +2 more
openaire   +4 more sources

CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation [PDF]

International Journal of Molecular Sciences, 2020
Brown adipose tissue (BAT) is a thermogenic organ in rodents and humans. In mice, the transplantation of BAT has been successfully used to combat obesity and its comorbidities. While such beneficial properties of BAT are now evident, the developmental and cellular origins of brown, beige, and white adipocytes have remained only poorly understood ...
Meike Dahlhaus, Julian Roos, Daniel Engel, Daniel Tews, Daniel Halbgebauer, Jan-Bernd Funcke, Sophie Kiener, Patrick J. Schuler, Johannes Döscher, Thomas K. Hoffmann, Julia Zinngrebe, Markus Rojewski, Hubert Schrezenmeier, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky   +15 more
openaire   +3 more sources

Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice

American Journal of Physiology - Endocrinology and Metabolism, 2020
Xin Cui, Bingzhong Xue, Fenfen Li
exaly   +2 more sources

Beige Fat Maintenance; Toward a Sustained Metabolic Health

Frontiers in Endocrinology, 2020
Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy.
Atefeh Rabiee
doaj   +1 more source

Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes [PDF]

Int J Mol Sci
Adipose tissue is conventionally recognized as a metabolic organ responsible for storing energy. However, a proportion of adipose tissue also functions as a thermogenic organ, contributing to the inhibition of weight gain and prevention of metabolic diseases.
Yang S, Liu Y, Wu X, Zhu R, Sun Y, Zou S, Zhang D, Yang X.   +7 more
europepmc   +3 more sources

RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]

, 2014
Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry, Curry, Edward, Myrsini Kaforou, Cinti, S, Cinti, Saverio, Saverio Cinti, Lemonia Chatzeli, Parker, MG, Kiskinis, E, Kiskinis, Evangelos, Kaforou, M, Frontini, A, Chatzeli, Lemonia, Montana, G, Chatzeli, L, Curry, E, Kaforou, Myrsini, Evangelos Kiskinis, Montana, Giovanni, Christian, Mark, Giovanni Montana, Frontini, Andrea, Mark Christian, Parker, Malcolm G., Christian, M, Malcolm G. Parker   +25 more
core   +1 more source

Neural control of white, beige and brown adipocytes [PDF]

International Journal of Obesity Supplements, 2015
Reports of brown-like adipocytes in traditionally white adipose tissue (WAT) depots occurred ~30 years ago, but interest in white adipocyte 'browning' only has gained attention more recently. We integrate some of what is known about the sympathetic nervous system (SNS) innervation of WAT and brown adipose tissue (BAT) with the few studies focusing on ...
T J, Bartness, V, Ryu
openaire   +2 more sources

The Beige Adipocyte as a Therapy for Metabolic Diseases [PDF]

International Journal of Molecular Sciences, 2019
Adipose tissue is traditionally categorized into white and brown relating to their function and morphology. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue more energetically active, with a greater number of ...
openaire   +3 more sources