Results 51 to 60 of about 59,004 (177)
IMPORTANCE OF IRON HOMEOSTASIS IN BEIGE AND BROWN ADIPOCYTES
, 2021 Beige/brown adipocytes are specialized for non-shivering thermogenesis, dissipating mitochondrial energy into heat via uncoupling protein 1 (UCP1), thereby contributing to whole-body energy expenditure.
Yook, Jinseon
core +1 more source
Towards a Better Understanding of Beige Adipocyte Plasticity [PDF]
Cells, 2019 Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased ...
Esther Paulo, Biao Wang
openaire +2 more sources
Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity [PDF]
Journal of Endocrinology, 2018 Numerous studies have suggested that beige adipocyte abundance is correlated with improved metabolic performance, but direct evidence showing that beige adipocyte expansion protects animals from the development of obesity is missing. Previously, we have described that the liver kinase b1 (LKB1) regulates beige adipocyte renaissance in subcutaneous ...
Paulo, Esther +4 more
openaire +4 more sources
Nicotine induces a dual effect on the beige-like phenotype in adipocytes [PDF]
Archives of Biological Sciences, 2019 Nicotine, the main component of cigarette smoke, affects white/brown adipocytes. Few studies have concentrated on beige adipocytes. In this study, 3T3-L1 cells were differentiated in the presence of nicotine (25, 50 and 100 μmol/L) during early ...
Chen Hui-Jian +5 more
doaj +1 more source
Advanced Science, 2023 N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li +16 more
doaj +1 more source
A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
Cell Reports, 2020 Summary: UCP1-dependent thermogenesis is studied to define new strategies to ameliorate obesity and type 2 diabetes; however, animal models are mostly limited to germline mutations of UCP1, which can effect adaptive changes in UCP1-independent pathways ...
Tenagne D. Challa +7 more
doaj +1 more source
TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis [PDF]
Nature Communications, 2020 AbstractIt has been suggested that beige fat thermogenesis is tightly controlled by epigenetic regulators that sense environmental cues such as temperature. Here, we report that subcutaneous adipose expression of the DNA demethylase TET1 is suppressed by cold and other stimulators of beige adipocyte thermogenesis.
Sneha Damal Villivalam +8 more
openaire +5 more sources
eLife, 2017 Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic ...
Yuwei Jiang +2 more
doaj +1 more source
Formation of thermogenic adipocytes: What we have learned from pigs
Fundamental Research, 2021 Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise.
Jianguo Zhao +4 more
doaj +1 more source
PCB126 blocks the thermogenic beiging response of adipocytes
Environmental Science and Pollution Research, 2019 Subcutaneous white adipose tissue is capable of becoming thermogenic in a process that is referred to as "beiging." Beiging is associated with activation of the uncoupling protein, UCP1, and is known to be important for preventing adipose hypertrophy and development of insulin resistance.
Francoise A. Gourronc +3 more
openaire +3 more sources