Results 31 to 40 of about 8,254 (159)

Thermogenic adipose tissue in energy regulation and metabolic health

Frontiers in Endocrinology, 2023
The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat cells that regulate energy balance. Both adipocytes share common morphological,
Siwen Xue, Derek Lee, Daniel C. Berry
doaj   +1 more source

Selective activation of PPARα maintains thermogenic capacity of beige adipocytes

iScience, 2023
Summary: Beige adipocytes are inducible thermogenic adipocytes used for anti-obesity treatment. Beige adipocytes rapidly lose their thermogenic capacity once external cues are removed.
Gentaro Egusa, Haruya Ohno, Gaku Nagano, Junji Sagawa, Hiroko Shinjo, Yutaro Yamamoto, Natsumi Himeno, Yoshimi Morita, Akinori Kanai, Ryuta Baba, Kazuhiro Kobuke, Kenji Oki, Masayasu Yoneda, Noboru Hattori   +13 more
doaj   +1 more source

Chrna2-driven CRE Is Expressed in Beige Adipocytes.

Endocrinology
Abstract Significant research interest has been focused on beige adipocytes, the activation of which improves glucose and lipid homeostasis, therefore representing new therapeutic opportunities for metabolic diseases. Various Cre/Lox-based strategies have been used to investigate the developmental history of beige adipocytes and how ...
Zhu K, Liu S, Huang Y, Zhang B, Houssein N, Wu J.   +5 more
europepmc   +3 more sources

Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes [PDF]

Int J Mol Sci
Adipose tissue is conventionally recognized as a metabolic organ responsible for storing energy. However, a proportion of adipose tissue also functions as a thermogenic organ, contributing to the inhibition of weight gain and prevention of metabolic diseases.
Yang S, Liu Y, Wu X, Zhu R, Sun Y, Zou S, Zhang D, Yang X.   +7 more
europepmc   +3 more sources

CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation [PDF]

International Journal of Molecular Sciences, 2020
Brown adipose tissue (BAT) is a thermogenic organ in rodents and humans. In mice, the transplantation of BAT has been successfully used to combat obesity and its comorbidities. While such beneficial properties of BAT are now evident, the developmental and cellular origins of brown, beige, and white adipocytes have remained only poorly understood ...
Meike Dahlhaus, Julian Roos, Daniel Engel, Daniel Tews, Daniel Halbgebauer, Jan-Bernd Funcke, Sophie Kiener, Patrick J. Schuler, Johannes Döscher, Thomas K. Hoffmann, Julia Zinngrebe, Markus Rojewski, Hubert Schrezenmeier, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky   +15 more
openaire   +3 more sources

Beige Fat Maintenance; Toward a Sustained Metabolic Health

Frontiers in Endocrinology, 2020
Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy.
Atefeh Rabiee
doaj   +1 more source

Neural control of white, beige and brown adipocytes [PDF]

International Journal of Obesity Supplements, 2015
Reports of brown-like adipocytes in traditionally white adipose tissue (WAT) depots occurred ~30 years ago, but interest in white adipocyte 'browning' only has gained attention more recently. We integrate some of what is known about the sympathetic nervous system (SNS) innervation of WAT and brown adipose tissue (BAT) with the few studies focusing on ...
T J, Bartness, V, Ryu
openaire   +2 more sources

The Beige Adipocyte as a Therapy for Metabolic Diseases [PDF]

International Journal of Molecular Sciences, 2019
Adipose tissue is traditionally categorized into white and brown relating to their function and morphology. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue more energetically active, with a greater number of ...
openaire   +3 more sources

Towards a Better Understanding of Beige Adipocyte Plasticity [PDF]

Cells, 2019
Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased ...
Esther Paulo, Biao Wang
openaire   +2 more sources

Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity [PDF]

Journal of Endocrinology, 2018
Numerous studies have suggested that beige adipocyte abundance is correlated with improved metabolic performance, but direct evidence showing that beige adipocyte expansion protects animals from the development of obesity is missing. Previously, we have described that the liver kinase b1 (LKB1) regulates beige adipocyte renaissance in subcutaneous ...
Paulo, Esther, Wu, Dongmei, Hecker, Peter, Zhang, Yun, Wang, Biao   +4 more
openaire   +4 more sources