Obesity Beige adipocytes-will they beat obesity?.
Nature Reviews Endocrinology, 2015 The mechanistic link between the FTO locus and risk of obesity has remained elusive. However, a new study presents compelling evidence suggesting that the browning of white adipocytes into beige adipocytes (together with regulation of thermogenesis ...
Sandholt, Camilla H. +3 more
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Lsd1 prevents age-programed loss of beige adipocytes. [PDF]
Proceedings of the National Academy of Sciences, 2017 Aging is accompanied by major changes in adipose tissue distribution and function. In particular, with time, thermogenic-competent beige adipocytes progressively gain a white adipocyte morphology.
Milica Tosic +17 more
core +5 more sources
Induction of Beige-Like Adipocytes in 3T3-L1 Cells [PDF]
Journal of Veterinary Medical Science, 2014 There are two types of brown adipocytes: classical brown adipocytes that form the brown fat depots and beige adipocytes that emerge in the white fat depots.
NARA, Takayuki +6 more
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Fighting obesity by targeting factors regulating beige adipocytes. [PDF]
Current Opinion in Clinical Nutrition & Metabolic Care, 2018 Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
Koliwad, Suneil K +2 more
core +7 more sources
Human beige adipocytes for drug discovery and cell therapy in metabolic diseases [PDF]
Nature Communications, 2020 Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic ...
Amar M. Singh +9 more
doaj +2 more sources
Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes [PDF]
Advanced Science, 2020 Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown.
Jin Li +25 more
doaj +2 more sources
Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice [PDF]
Molecular MetabolismObjective: Platelet Derived Growth Factor Receptor Beta (Pdgfrβ) suppresses the formation of cold temperature-induced beige adipocytes in aged mammals.
Abigail M. Benvie, Daniel C. Berry
doaj +2 more sources
Exploring the Multifaceted Life of Beige Adipocytes
Obesity has become a major global health concern, with the number of individuals affected rising dramatically over the past several decades. Obesity is closely linked to a range of chronic diseases and contributes significantly to morbidity and mortality
Lin, Zeran
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Optogenetics Sheds Light on Brown and Beige Adipocytes. [PDF]
J Cell Signal, 2023 Excessive food intake leads to lipid accumulation in white adipose tissue, triggering inflammation, cellular stress, insulin resistance, and metabolic syndrome. In contrast, the dynamic energy expenditure and heat generation of brown and beige adipose tissue, driven by specialized mitochondria, render it an appealing candidate for therapeutic ...
Brown AC.
europepmc +3 more sources
mTOR signaling in Brown and Beige adipocytes: implications for thermogenesis and obesity [PDF]
Nutrition & Metabolism, 2019 Brown and beige adipocytes are mainly responsible for nonshivering thermogenesis or heat production, despite the fact that they have distinguished features in distribution, developmental origin, and functional activation.
Yuqing Ye +3 more
doaj +2 more sources