Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes [PDF]
International Journal of Molecular Sciences, 2020 Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form. However, the biological pathways involved in the browning process are still unclear.
Inês Vieira da Silva +5 more
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Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes. [PDF]
Nat Commun, 2022 AbstractThermogenic adipocytes generate heat to maintain body temperature against hypothermia in response to cold. Although tight regulation of thermogenesis is required to prevent energy sources depletion, the molecular details that tune thermogenesis are not thoroughly understood.
Han JS +14 more
europepmc +4 more sources
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype. [PDF]
PLoS ONE, 2016 Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin.
Omar Abdul-Rahman +18 more
doaj +1 more source
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
doaj +1 more source
A Method to Induce Brown/Beige Adipocyte Differentiation from Murine Preadipocytes
Bio-Protocol, 2021 Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend to ...
Andréa Rocha +3 more
doaj +1 more source
Metabolic programming of a beige adipocyte phenotype by genistein [PDF]
Molecular Nutrition & Food Research, 2016 ScopePromoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.Methods and resultsWe observed that application of genistein to 3T3‐L1 adipocytes changed the lipid distribution from large droplets to a multilocular distribution,
Aziz SA +5 more
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ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation
Frontiers in Endocrinology, 2020 When exposed to cold temperatures, mice increase their thermogenic capacity by an expansion of brown adipose tissue mass and the formation of brite/beige adipocytes in white adipose tissue depots.
Sebastian Müller +8 more
doaj +1 more source
Genetically prolonged beige fat in male mice confers long-lasting metabolic health
Nature Communications, 2023 A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, beige adipocytes quickly transition into white adipocytes upon removing stimuli.
Ruifan Wu +19 more
doaj +1 more source
Adaptive thermogenesis in adipocytes: Is beige the new brown? [PDF]
Genes & Development, 2013 One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat.
Wu, Jun +2 more
openaire +4 more sources
American Journal of Physiology - Endocrinology and Metabolism, 2020 Xin Cui, Bingzhong Xue, Fenfen Li
exaly +2 more sources