Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes [PDF]
AdipocyteIn mammals, brown adipose tissue (BAT) and beige adipocytes in white adipose tissue (WAT) play pivotal roles in maintaining body temperature and energy metabolism.
Yong Geun Jeon, Sun Won Kim, Jae Bum Kim
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Aquaglyceroporins are differenctially expressed in beige and white adipocytes [PDF]
International Journal of Molecular Sciences, 2021 Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form.
Gumà i Garcia, Anna Maria +5 more
core +6 more sources
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
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A Smooth Muscle-Like Origin for Beige Adipocytes [PDF]
Cell Metabolism, 2014 SummaryThermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure.
Lokurkar, Isha +12 more
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Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes [PDF]
Journal of Biological Chemistry, 2021 International audienceActivation of energy-dissipating brown/beige adipocytes represents an attractive therapeutic strategy against metabolic disorders. While lactate is known to induce beiging through the regulation of Ucp1 gene expression, the role of ...
Isabelle Ader +2 more
exaly +3 more sources
Beige adipocytes contribute to breast cancer progression [PDF]
Oncology Reports, 2020 Adipocytes are the main stromal cells in the mammary microenvironment, and crosstalk between adipocytes and breast cancer cells may play a critical and important role in cancer maintenance and progression.
Lotufo, Cecilia Maricel +6 more
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Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour ...
Michaela Kripnerová +7 more
core +6 more sources
The Common and Distinct Features of Brown and Beige Adipocytes [PDF]
Trends in Endocrinology and Metabolism, 2018 Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat possess thermogenic properties in addition to common morphological and biochemical characteristics, including multilocular lipid droplets and cristae-dense mitochondria ...
Shingo Kajimura
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Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes. [PDF]
Nat Commun, 2022 Thermogenic adipocytes generate heat to maintain body temperature against hypothermia in response to cold. Although tight regulation of thermogenesis is required to prevent energy sources depletion, the molecular details that tune thermogenesis are not ...
Han JS +14 more
europepmc +5 more sources
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype. [PDF]
PLoS ONE, 2016 Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin.
Omar Abdul-Rahman +18 more
doaj +3 more sources