The Common and Distinct Features of Brown and Beige Adipocytes [PDF]
Trends in Endocrinology and Metabolism, 2018 Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat possess thermogenic properties in addition to common morphological and biochemical characteristics, including multilocular lipid droplets and cristae-dense mitochondria ...
Shingo Kajimura
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Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes [PDF]
AdipocyteIn mammals, brown adipose tissue (BAT) and beige adipocytes in white adipose tissue (WAT) play pivotal roles in maintaining body temperature and energy metabolism.
Yong Geun Jeon, Sun Won Kim, Jae Bum Kim
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Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes [PDF]
Advanced Science, 2020 Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown.
Jin Li +25 more
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Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice [PDF]
Molecular MetabolismObjective: Platelet Derived Growth Factor Receptor Beta (Pdgfrβ) suppresses the formation of cold temperature-induced beige adipocytes in aged mammals.
Abigail M. Benvie, Daniel C. Berry
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mTOR signaling in Brown and Beige adipocytes: implications for thermogenesis and obesity [PDF]
Nutrition & Metabolism, 2019 Brown and beige adipocytes are mainly responsible for nonshivering thermogenesis or heat production, despite the fact that they have distinguished features in distribution, developmental origin, and functional activation.
Yuqing Ye +3 more
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Optogenetics Sheds Light on Brown and Beige Adipocytes. [PDF]
J Cell Signal, 2023 Excessive food intake leads to lipid accumulation in white adipose tissue, triggering inflammation, cellular stress, insulin resistance, and metabolic syndrome. In contrast, the dynamic energy expenditure and heat generation of brown and beige adipose tissue, driven by specialized mitochondria, render it an appealing candidate for therapeutic ...
Brown AC.
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Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes [PDF]
Journal of Biological Chemistry, 2021 Isabelle Ader +2 more
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Thermogenic Activation Downregulates High Mitophagy Rate in Human Masked and Mature Beige Adipocytes [PDF]
International Journal of Molecular Sciences, 2020 Zoltan Balajthy +2 more
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Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Miroslava Cedikova +7 more
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Effects of exercise on brown and beige adipocytes. [PDF]
Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise.
Dewal RS, Stanford KI.
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