Beige Fat Maintenance; Toward a Sustained Metabolic Health [PDF]
Frontiers in Endocrinology, 2020 Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy.
Atefeh Rabiee
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Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis [PDF]
Advanced Science, 2023 N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li +16 more
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Silver nanoparticles inhibit beige fat function and promote adiposity [PDF]
Molecular Metabolism, 2019 Objective: Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution of environmental pollutants frequent in modern society.
Lishu Yue +15 more
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Stepping Up Human Beige Fat Cell Production [PDF]
Cell Reports, 2018 Beige fat cells hold significant promise for reducing obesity and metabolic disease. Su et al. (2018) present a robust method to produce human beige adipocytes from pluripotent stem cells via the generation of an expandable intermediary population of ...
Wenli Yang, Patrick Seale
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Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis [PDF]
Nature Communications, 2023 Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain largely unknown. Here, we show that adipocyte YAP/
Xun Huang +9 more
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Insights into the neurochemical signature of the Innervation of Beige Fat [PDF]
Molecular Metabolism, 2018 The potential for brown adipose tissue (BAT) to be targeted as a therapeutic option to combat obesity has been heightened by the discovery of a brown-like form of inducible "beige" adipose tissue in white fat which has overlapping structural and functional properties to "classical" BAT.
Nicole Wiedmann +2 more
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Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity [PDF]
Scientific Reports, 2022 Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%.
Mojgan Nazari +10 more
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Control of brown and beige fat development [PDF]
Nature Reviews Molecular Cell Biology, 2016 Brown and beige adipocytes expend chemical energy to produce heat and are therefore important in regulating body temperature and body weight. Brown adipocytes develop in discrete and relatively homogenous depots of brown adipose tissue, whereas beige adipocytes are induced to develop in white adipose tissue in response to certain stimuli - notably ...
Patrick Seale, Wenshan Wang
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IL-25–induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice [PDF]
PLoS Biology, 2021 Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose ...
Lingyi Li +12 more
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Morphogenetics in brown, beige and white fat development [PDF]
Adipocyte, 2016 Brown and beige (or brite) fat cells are capable of evoking non-shivering thermogenesis in response to cold and β-adrenergic stimulation. By metabolizing lipids and carbohydrate via uncoupled respiration these cells directly convert energy to heat.
Stephen Farmer, Jean Z Lin
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