Results 1 to 10 of about 69,972 (249)
The Journal of Poultry Science, 2023 s: Skeletal muscles have a high demand for ATP, which is met largely through mitochondria oxidative phosphorylation. Autophagy is essential for the maintenance of skeletal muscle mass under catabolic conditions.
Kazuki Nakashima, Aiko Ishida
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Thermogenic Capacity of Human White-Fat: The Actual Picture†
Proceedings, 2019 AIM: Cold exposure and exercise may increase thermogenic capacity of white adipose tissue (WAT), which could subsequently enhance energy expenditure and body weight loss.
Petros C. Dinas +20 more
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Advanced Biomedical Research, 2018 Background: Uncoupling protein-1 (UCP-1) is the index protein of the brown adipose tissue (BAT), used in the obesity studies. We evaluated the effects of thymoquinone (TQ), hydroalcoholic, and hexane extracts of Nigella sativa, on the UCP-1 gene ...
Amin Mahmoudi +3 more
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ANXA1 improves mitochondrial homeostasis through uncoupling protein 1 in diabetic nephropathy
Journal of Advanced ResearchIntroduction: Diabetic nephropathy (DN) is a major public health concern. Our previous study found that annexin A1 (ANXA1) alleviated DN by improving mitochondrial homeostasis. However, the underlying mechanism is not fully clear yet.
Zi-Han Li +10 more
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Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes
CellsCatecholamines are crucial signaling molecules that initiate thermogenesis in adipocytes through beta-adrenergic receptors (ADRBs). Adipocyte catecholamine resistance is a common feature of pediatric obesity, often impeding weight loss and the ...
Katalin Gyurina +8 more
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Journal of Lipid ResearchObesity leads to numerous illnesses and metabolic disorders, with lysophosphatidylcholine levels declining in obese patients. However, the physiological role of lysophosphatidylcholine and the regulatory mechanisms involved in modulating obesity remain ...
Rui Wang +7 more
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Evolution of UCP1 Transcriptional Regulatory Elements Across the Mammalian Phylogeny
Frontiers in Physiology, 2017 Uncoupling protein 1 (UCP1) permits non-shivering thermogenesis (NST) when highly expressed in brown adipose tissue (BAT) mitochondria. Exclusive to placental mammals, BAT has commonly been regarded to be advantageous for thermoregulation in hibernators,
Michael J. Gaudry, Kevin L. Campbell
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Moderate SIRT1 overexpression protects against brown adipose tissue inflammation
Molecular Metabolism, 2020 Objective: Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance.
Carmen Escalona-Garrido +12 more
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Journal of Ginseng Research, 2019 Background: Panax ginseng Meyer is known as a conventional herbal medicine, and ginsenoside Rg1, a steroid glycoside, is one of its components. Although Rg1 has been proved to have an antiobesity effect, the mechanism of this effect and whether it ...
Kippeum Lee +4 more
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Uncoupling protein-1 as a target for the treatment of obesity/insulin resistance
Frontiers in Physiology, 2015 Presence of brown adipose tissue (BAT), characterised by the expression of the thermogenic uncoupling protein 1 (UCP1), has recently been described in adult humans.
Anne-Laure ePoher +3 more
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