Results 1 to 10 of about 89,481 (251)

Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort [PDF]

Molecular Metabolism, 2020
Objectives: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes.
Agné Kulyté, Veroniqa Lundbäck, Cecilia M. Lindgren, Jian'an Luan, Luca A. Lotta, Claudia Langenberg, Peter Arner, Rona J. Strawbridge, Ingrid Dahlman   +8 more
doaj   +4 more sources

BK channel deficiency promotes lipolysis via an AKT-independent activation of the cAMP/PKA/HSL pathway [PDF]

Journal of Lipid Research
Adipocyte lipolysis mobilizes stored triglycerides during energy deprivation, a process tightly regulated to maintain metabolic homeostasis. The large conductance calcium-activated potassium channel (BK) is present in adipocytes and is involved in ...
Jin Zhang, Xin Shi, Mengxuan Zhang, Yuying Han, Guang Yang, Ruiyang Li, Feng Zhao, Ping Liu, Xinxin Wen, Wenxuan Wei, Bojing Zuo, Biao Zheng, Hongshan Liu, Wenjing Lu, Meili Wang, Zhifei Zhang, Haixia Huang   +16 more
doaj   +2 more sources

Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway

Molecular Metabolism, 2023
Objectives: Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and indirectly through signaling in the brain.
Matthäus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Scherer   +5 more
doaj   +1 more source

Phospholipid Degradation Kinetics of Pork during Combined High-Pressure and Thermal Treatments [PDF]

Shipin Kexue, 2023
In order to explore the effect of combined high-pressure and thermal treatment on the lipolysis of phospholipids in pork, the phospholipid degradation kinetics of pork was studied in the 300 to 700 MPa pressure range and in the 20 to 60 ℃ temperature ...
YUN Zhoumiao, HUANG Yechuan, PENG Chunlei, ZHAO Jing, ZHANG Keyuan
doaj   +1 more source

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes [PDF]

PeerJ, 2014
We determined the effect of butyrate and other short-chain fatty acids (SCFA) on rates of lipolysis in 3T3-L1 adipocytes. Prolonged treatment with butyrate (5 mM) increased the rate of lipolysis approximately 2–3-fold.
John M. Rumberger, Jonathan R.S. Arch, Allan Green   +2 more
doaj   +2 more sources

Growth hormone stimulates lipolysis in mice but not in adipose tissue or adipocyte culture

Frontiers in Endocrinology, 2023
The inhibitory effect of growth hormone (GH) on adipose tissue growth and the stimulatory effect of GH on lipolysis are well known, but the mechanisms underlying these effects are not completely understood.
Lidan Zhao, Honglin Jiang
doaj   +1 more source

Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases

Journal of Lipid Research, 2005
Hormone-sensitive lipase (HSL) contributes importantly to the hydrolysis of cholesteryl ester in steroidogenic tissues, releasing the cholesterol required for adrenal steroidogenesis.
Yassine Ben Ali, Frédéric Carrière, Robert Verger, Stefan Petry, Günter Muller, Abdelkarim Abousalham   +5 more
doaj   +1 more source

Sensitive assay for hormone-sensitive lipase using NBD-labeled monoacylglycerol to detect low activities in rat adipocytes

Journal of Lipid Research, 2005
The recent finding that p-nitrobenzofurazan (NBD)-FA is incorporated into and released from the acylglycerols of isolated rat adipocytes in an insulin-sensitive manner [G. Müller, H. Jordan, C. Jung, H. Kleine, and S. Petry. 2003. Biochimie.
Stefan Petry, Yassine Ben Ali, Henri Chahinian, Holger Jordan, Horst Kleine, Günter Müller, Frédéric Carrière, Abdelkarim Abousalham   +7 more
doaj   +1 more source

Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia

Cell Death and Disease, 2021
Cancer cachexia is a metabolic disorder characterized by skeletal muscle wasting and white adipose tissue browning. Specific functions of several hormones, growth factors, and cytokines derived from tumors can trigger cachexia.
Wenjun Hu, Hairong Xiong, Zeyuan Ru, Yan Zhao, Yali Zhou, Kairu Xie, Wen Xiao, Zhiyong Xiong, Cheng Wang, Changfei Yuan, Jian Shi, Quansheng Du, Xiaoping Zhang, Hongmei Yang   +13 more
doaj   +1 more source

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

Journal of Lipid Research, 2005
This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder, James M. Esselstyn, Kate Loughney, Sharon L. Wolda, Vincent A. Florio   +4 more
doaj   +1 more source