Results 31 to 40 of about 68,563 (264)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. [PDF]

PLoS ONE, 2013
In obesity, high levels of tumor necrosis factor α (TNFα) stimulate lipolysis in adipocytes, leading to hyperlipidemia and insulin resistance. Thiazolidinediones (TZDs), the insulin-sensitizing drugs, antagonize TNFα-induced lipolysis in adipocytes ...
Juu-Chin Lu, Yu-Tzu Chang, Chih-Tien Wang, Yu-Chun Lin, Chun-Ken Lin, Zhong-Sheng Wu   +5 more
doaj   +1 more source

Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration

Molecular Metabolism, 2023
Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes.
Melissa A. Linden, Susan J. Burke, Humza A. Pirzadah, Tai-Yu Huang, Heidi M. Batdorf, Walid K. Mohammed, Katarina A. Jones, Sujoy Ghosh, Shawn R. Campagna, J. Jason Collier, Robert C. Noland   +10 more
doaj   +1 more source

Relationship between cyclic AMP production and lipolysis induced by forskolin in rat fat cells.

Journal of Lipid Research, 1992
Forskolin (7 beta-acetoxy-8, 13-epoxy-1 alpha,6 beta,9 alpha-trihydroxy-labd-14-ene-11-one) induced both cyclic AMP production and lipolysis in intact fat cells, but stimulated lipolysis without increasing cyclic AMP at a concentration of 10(-5) M ...
H Okuda, C Morimoto, T Tsujita
doaj   +1 more source

Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice. [PDF]

PLoS ONE, 2013
Adipose tissue expressed endogenous cystathionine gamma lyase (CSE)/hydrogen sulfide (H2S) system. H2S precursor inhibited catecholamine stimulated lipolysis.
Bin Geng, Bo Cai, Feng Liao, Yang Zheng, Qiang Zeng, Xiaofang Fan, Yongsheng Gong, Jichun Yang, Qing Hua Cui, Chaoshu Tang, Guo Heng Xu   +10 more
doaj   +1 more source

Milking frequency and dairy cow susceptibility to lipolysis interact to alter milk lipolysis and composition

Journal of Dairy Science
: Lipolysis is an ongoing issue for the French dairy industry that must be minimized. Milk lipolysis is defined as the hydrolysis of triglycerides, the major component of milk fat, resulting in the release of short-chain fatty acids responsible for ...
C. Hurtaud, L. Bernard, A. Rau, C. Cebo
doaj   +1 more source

Gastrointestinal lipolysis of lipid-based excipients intended for the oral drug delivery of poorly water-soluble drugs

Oléagineux, Corps gras, Lipides, 2010
Labrasol® and Gelucire® 44/14 are lipid-based excipients used for the oral drug delivery of poorly water-soluble drugs. These macrogolglycerides are composed of acylglycerols and PEG esters, potential substrates of digestive lipases.
Fernandez Sylvie, Carrière Frédéric, Jannin Vincent   +2 more
doaj   +1 more source

Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis. [PDF]

PLoS ONE, 2016
OBJECTIVES:Numerous genetic loci have been associated with measures of central fat accumulation, such as waist-to-hip ratio adjusted for body mass index (WHRadjBMI).
Rona J Strawbridge, Helmut Laumen, Anders Hamsten, Michaela Breier, Harald Grallert, Hans Hauner, Peter Arner, Ingrid Dahlman   +7 more
doaj   +1 more source

Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia

Frontiers in Oncology, 2022
Adipose tissue inflammation is observed in multiple metabolically-altered states including cancer-associated cachexia and obesity. Although cachexia is a syndrome of adipose loss and obesity is a disease of adipose excess, both pathologies demonstrate ...
Aakash Y. Gandhi, Aakash Y. Gandhi, Jinhai Yu, Jinhai Yu, Jinhai Yu, Arun Gupta, Tong Guo, Tong Guo, Puneeth Iyengar, Puneeth Iyengar, Puneeth Iyengar, Rodney E. Infante, Rodney E. Infante, Rodney E. Infante, Rodney E. Infante   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source