Results 41 to 50 of about 89,481 (251)

Gastrointestinal lipolysis of lipid-based excipients intended for the oral drug delivery of poorly water-soluble drugs

open access: yesOléagineux, Corps gras, Lipides, 2010
Labrasol® and Gelucire® 44/14 are lipid-based excipients used for the oral drug delivery of poorly water-soluble drugs. These macrogolglycerides are composed of acylglycerols and PEG esters, potential substrates of digestive lipases.
Fernandez Sylvie   +2 more
doaj   +1 more source

Heritability of milk lipolysis in French Alpine goats

open access: yes, 2023
International audienceMilk lipolysis, i.e. the hydrolysis of milk triglycerides, is not routinely measured and its occurrence and genetic determinism can therefore be hardly studied.
Bernard, Laurence   +9 more
core   +3 more sources

Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis. [PDF]

open access: yesPLoS ONE, 2016
OBJECTIVES:Numerous genetic loci have been associated with measures of central fat accumulation, such as waist-to-hip ratio adjusted for body mass index (WHRadjBMI).
Rona J Strawbridge   +7 more
doaj   +1 more source

Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia

open access: yesFrontiers in Oncology, 2022
Adipose tissue inflammation is observed in multiple metabolically-altered states including cancer-associated cachexia and obesity. Although cachexia is a syndrome of adipose loss and obesity is a disease of adipose excess, both pathologies demonstrate ...
Aakash Y. Gandhi   +14 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

open access: yesAdvanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia   +13 more
wiley   +1 more source

Hormone-stimulated lipolysis in isolated fat cells from “young” and “old” rats

open access: yesJournal of Lipid Research, 1973
The biphasic nature of the lipolytic dose-response curve of epinephrine in fat cells from “young” rats (40–45 days) was confirmed. The first phase (Lipolysis I) occurred at concentrations of from 10–7 m to 3 × 10–6 m.
Elizabeth A. Miller, Donald O. Allen
doaj   +1 more source

Shared genetic loci for body fat storage and adipocyte lipolysis in humans

open access: yesScientific Reports, 2022
Total body fat and central fat distribution are heritable traits and well-established predictors of adverse metabolic outcomes. Lipolysis is the process responsible for the hydrolysis of triacylglycerols stored in adipocytes.
Agné Kulyté   +4 more
doaj   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

open access: yesAdvanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian   +12 more
wiley   +1 more source

Dissection of surface area-dependent lipolysis at a single organelle level

open access: yesCell Reports
Summary: Lipid droplets are dynamic organelles whose size and number signify their role in energy. However, owing to cellular heterogeneity and technological limitations, the relationship between the lipolytic ability and lipid droplet morphology is ...
Chengxin Ma   +9 more
doaj   +1 more source

Effects of epinephrine, corticotropin, and thyrotropin on lipolysis and glucose oxidation in rat adipose tissue

open access: yesJournal of Lipid Research, 1967
(Log dose)-response curves have been determined for lipolysis and for the conversion of glucose-14C to 14CO2 by adipose tissue from rats in the presence of epinephrine, corticotropin, and thyrotropin.
George A. Bray
doaj   +1 more source

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