Uncoupling protein 1 inhibits mitochondrial reactive oxygen species generation and alleviates acute kidney injury [PDF]
EBioMedicine, 2019 Background: Uncoupling protein 1 (UCP1) is predominantly found in brown adipose tissue mitochondria, and mediates energy dissipation to generate heat rather than ATP via functional mitochondrial uncoupling.
Ping Jia +5 more
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Uncoupling Protein 1 Does Not Produce Heat without Activation. [PDF]
Int J Mol Sci, 2022 Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an
Li Y, Fromme T.
europepmc +5 more sources
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
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Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress. [PDF]
PLoS ONE, 2018 Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly ...
Laura M Bond +2 more
doaj +3 more sources
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study [PDF]
BMC Medical Genetics, 2018 Background Obesity is one of the main causes of morbidity and mortality worldwide. More than 120 genes have been shown to be associated with obesity related phenotypes.
Shahanas Chathoth +8 more
doaj +3 more sources
Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation [PDF]
Life Science Alliance, 2018 Quantification of substrate fluxes in brown adipocytes clarifies contributors to extracellular acidification, identifies a futile cycle of lipolysis and re-esterification, and suggests a role for glycogen during activation.
Sabine Schweizer +3 more
doaj +3 more sources
FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
Cell Reports, 2015 Fibroblast growth factor 21 (FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in adipose tissues, suggesting that UCP1-dependent thermogenesis may drive FGF21 action.
Michelle M. Kwon +4 more
doaj +4 more sources
Structural basis of purine nucleotide inhibition of human uncoupling protein 1. [PDF]
Sci Adv, 2023 Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation.
Jones SA +14 more
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Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1β production. [PDF]
Sci Adv, 2021 The mitochondrial protein UCP1 has potent therapeutic effects on vascular inflammation and atherosclerosis.
Gu P +14 more
europepmc +2 more sources
Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1). [PDF]
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2019 Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis.
P. Ježek, M. Jabůrek, R. K. Porter
semanticscholar +3 more sources