CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression [PDF]
Antioxidants, 2022 Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditary ...
Ching-Fang Chang +6 more
doaj +2 more sources
Uncoupling protein 1 (UCP1) of brown adipocyte, the only uncoupler: historical perspective [PDF]
Frontiers in Endocrinology, 2011 Uncoupling protein 1 - UCP1, is a unique mitochondrial membranous protein devoted to adaptive thermogenesis, a specialized function operated by the highly specialized oxidative brown adipocytes.
Daniel eRicquier
doaj +4 more sources
Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis [PDF]
Molecular Metabolism, 2022 Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans.
Riccardo Cavalieri +7 more
doaj +2 more sources
Keys to the switch of fat burning: stimuli that trigger the uncoupling protein 1 (UCP1) activation in adipose tissue. [PDF]
Lipids Health DisAs one of the main pathogenic factors of cardiovascular and cerebrovascular diseases, the incidence of metabolic diseases such as adiposity and metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing annually.
Gong D +8 more
europepmc +2 more sources
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus [PDF]
Journal of Lipid Research, 1998 Uncoupling protein-1 (UCP-1) activity in brown adipose tissue increases thermogenesis, contributes to facultative energy expenditure in humans, and has been implicated in the pathogenesis of rodent obesity.
Harald Esterbauer +6 more
doaj +3 more sources
Journal of Obesity & Metabolic Syndrome, 2018 Background : Uncoupling protein 1 (UCP1) plays an important role in increasing energy expenditure; thus, it is being considered as a new target for preventing obesity and metabolic complications.
Hyunjung Choi, Chu-Sook Kim, Rina Yu
doaj +2 more sources
Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity
Molecular Metabolism, 2018 Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
Tobias Fromme +11 more
doaj +2 more sources
Mitochondrial Brown Fat Uncoupling Protein 1 [PDF]
Definitions, 2020 Mitochondrial brown fat uncoupling protein 1 (307 aa, ~33 kDa) is encoded by the UCP1 gene.
semanticscholar +2 more sources
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis. [PDF]
Trends in Biochemical SciencesIn mitochondria, the oxidation of nutrients is coupled to ATP synthesis by the generation of a protonmotive force across the mitochondrial inner membrane.
Scott A Jones +3 more
semanticscholar +4 more sources
Pig has no uncoupling protein 1.
Biochemical and Biophysical Research Communications, 2017 Brown adipose tissue (BAT) is critical for mammal's survival in the cold environment. Uncoupling protein 1 (UCP1) is responsible for the non-shivering thermogenesis in the BAT. Pig is important economically as a meat-producing livestock. However, whether BAT or more precisely UCP1 protein exists in pig remains a controversy. The objective of this study
Lianjie Hou +5 more
semanticscholar +3 more sources