Results 41 to 50 of about 2,019,877 (178)

Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20
Stephen B. Smith, Craig R. Sweatt, Gordon E. Carstens   +2 more
doaj   +1 more source

Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system.

American Journal of Physiology. Endocrinology and Metabolism, 2019
Uncoupling protein 1 provides non-shivering thermogenesis fueled by the dissipation of energy from macronutrients in brown and brite adipocytes. The availability of thermogenic fuels is facilitated by the uptake of extracellular glucose. This conjunction
Stefanie Maurer, T. Fromme, Sabine Mocek, Anika Zimmermann, M. Klingenspor   +4 more
semanticscholar   +1 more source

Uncoupling Protein 2 Increases Blood Pressure in DJ‐1 Knockout Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The redox‐sensitive chaperone DJ‐1 and uncoupling protein 2 are protective against mitochondrial oxidative stress. We previously reported that renal‐selective depletion and germline deletion of DJ‐1 increases blood pressure in mice. This study
Carmen De Miguel, William C. Hamrick, Randee Sedaka, Sudha Jagarlamudi, Laureano D. Asico, Pedro A. Jose, Santiago Cuevas   +6 more
doaj   +1 more source

Mitochondrial uncoupling protein 1 expression in thymocytes

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out mice. UCP 1 is also shown to be present in thymocytes isolated from rat.
Adams, Alison E., Carroll, Audrey M., Fallon, Padraic G., Porter, Richard K.   +3 more
openaire   +4 more sources

Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1

Molecular Nutrition & Food Research, 2019
Scope: Brown adipose tissue (BAT) dissipates energy through uncoupling protein 1 (UCP1) and has been proposed as an anti-obesity target. We previously reported that high fat (HF) diet enriched in eicosapentaenoic acid (EPA) significantly increased UCP1 ...
M. Pahlavani, L. Ramalingam, Emily K. Miller, S. Scoggin, Kalhara R. Menikdiwela, N. Kalupahana, W. Festuccia, N. Moustaid‐Moussa   +7 more
semanticscholar   +1 more source

Possible involvement of uncoupling protein 1 in appetite control by leptin [PDF]

Experimental Biology and Medicine, 2011
Leptin reduces body fat by decreasing food intake and increasing energy expenditure. Uncoupling protein (UCP) 1, a key molecule for brown adipose tissue (BAT) thermogenesis, was reported to contribute to the stimulatory effect of leptin on energy expenditure.
Okamatsu-Ogura, Yuko, Nio-Kobayashi, Junko, Iwanaga, Toshihiko, Terao, Akira, Kimura, Kazuhiro, Saito, Masayuki   +5 more
openaire   +3 more sources

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

Phosphorus Supplementation Mitigates Perivascular Adipose Inflammation–Induced Cardiovascular Consequences in Early Metabolic Impairment

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The complexity of the interaction between metabolic dysfunction and cardiovascular complications has long been recognized to extend beyond simple perturbations of blood glucose levels.
Haneen S. Dwaib, Ghina Ajouz, Ibrahim AlZaim, Rim Rafeh, Ali Mroueh, Nahed Mougharbil, Marie‐Elizabeth Ragi, Marwan Refaat, Omar Obeid, Ahmed F. El‐Yazbi   +9 more
doaj   +1 more source

Mitochondrial proton leak and the uncoupling protein 1 homologues

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001
Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of ...
Stuart, J.A, Cadenas, S, Jekabsons, M.B, Roussel, D, Brand, M.D   +4 more
openaire   +2 more sources

The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation [PDF]

The Journal of Physiology, 2016
Key points Both uncoupling protein 1 (UCP1) and UCP3 are important for mammalian thermoregulation. UCP1 and UCP3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respectively. Lipopolysaccharide thermogenesis requires skeletal muscle UCP3 but not UCP1. Acute noradrenaline‐induced hyperthermia requires UCP1 but not
Riley, Christopher L., Dao, Christine, Kenaston, M. Alexander, Muto, Luigina, Kohno, Shohei, Nowinski, Sara M., Solmonson, Ashley D., Pfeiffer, Matthew, Sack, Michael N., Lu, Zhongping, FIERMONTE, Giuseppe, Sprague, Jon E., Mills, Edward M.   +12 more
openaire   +3 more sources