Results 61 to 70 of about 2,019,877 (178)

Electrophysiological Characterization of Mitochondrial Uncoupling Protein 1

Biophysical Journal, 2009
Uncoupling proteins (UCP1- UCP5) are integral transport proteins of the inner mitochondrial membrane (IMM). They mediate transmembrane ion leak, thus dissipating the electrochemical proton gradient across the IMM and uncoupling mitochondrial respiration and ATP synthesis.
Fedorenko, Andriy, Lishko, Polina, Kirichok, Yuriy   +2 more
openaire   +1 more source

ANXA1 improves mitochondrial homeostasis through uncoupling protein 1 in diabetic nephropathy

Journal of Advanced Research
Introduction: Diabetic nephropathy (DN) is a major public health concern. Our previous study found that annexin A1 (ANXA1) alleviated DN by improving mitochondrial homeostasis. However, the underlying mechanism is not fully clear yet.
Zi-Han Li, Lu Fang, Liang Wu, Dong-Yuan Chang, Manyuan Dong, Liang Ji, Qi Zhang, Ming-Hui Zhao, Sydney C.W. Tang, Lemin Zheng, Min Chen   +10 more
doaj   +1 more source

Uncoupling protein 1 expression in adipocytes derived from skeletal muscle fibro/adipogenic progenitors is under genetic and hormonal control

Journal of Cachexia, Sarcopenia and Muscle, 2018
Intramuscular fatty infiltration is generally associated with the accumulation of white adipocytes in skeletal muscle and unfavourable metabolic outcomes.
Tatiane Gorski, S. Mathes, J. Krützfeldt   +2 more
semanticscholar   +1 more source

Stimulation of uncoupling protein 1 expression by β-alanine in brown adipocytes

Archives of Biochemistry and Biophysics, 2022
Carnosine, which is abundant in meat, is a dipeptide composed of β-alanine and histidine, known to afford various health benefits. It has been suggested that carnosine can elicit an anti-obesity effect via induction and activation of brown/beige adipocytes responsible for non-shivering thermogenesis.
Tsukasa Hamaoka, Xiajie Fu, Shozo Tomonaga, Osamu Hashimoto, Masaru Murakami, Masayuki Funaba   +5 more
openaire   +2 more sources

Mitochondrial Uncoupling Protein 1 Overexpression Increases Yield in Nicotiana tabacum under Drought Stress by Improving Source and Sink Metabolism

Frontiers in Plant Science, 2017
Mitochondrial uncoupling proteins (UCPs) sustain mitochondrial respiration independent of intracellular ATP concentration. Uncoupled respiration is particularly beneficial under stress conditions, during which both photosynthesis and respiration may be ...
P. Barreto, J. Yassitepe, Z. Wilson, P. Arruda   +3 more
semanticscholar   +1 more source

Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes

Cells
Catecholamines are crucial signaling molecules that initiate thermogenesis in adipocytes through beta-adrenergic receptors (ADRBs). Adipocyte catecholamine resistance is a common feature of pediatric obesity, often impeding weight loss and the ...
Katalin Gyurina, Ádám Radványi, László Sasi-Szabó, Enikő Felszeghy, Emese Rácz, Gábor Méhes, Andrea Kádár, Csaba Fekete, Tamás Röszer   +8 more
doaj   +1 more source

Sarcolipin and Uncoupling Protein 1 play distinct roles in diet induced thermogenesis and do not compensate for one another

Obesity, 2016
It is well known that uncoupling protein 1 (UCP1) in brown adipose tissue plays an important role in diet‐induced thermogenesis. In this study, whether sarcolipin (SLN), a regulator of sarco/endoplasmic reticulum Ca2+‐ATPase pump in muscle, is also an ...
Leslie A. Rowland, S. Maurya, N. Bal, L. Kozak, M. Periasamy   +4 more
semanticscholar   +1 more source

1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity

Journal of Lipid Research
Obesity leads to numerous illnesses and metabolic disorders, with lysophosphatidylcholine levels declining in obese patients. However, the physiological role of lysophosphatidylcholine and the regulatory mechanisms involved in modulating obesity remain ...
Rui Wang, Tianfu Zhu, Jingxian Lu, Mengke Cheng, Xingyun Wang, Xirong Guo, Shan Huang, Jianfang Gao   +7 more
doaj   +1 more source

Insulin and the β3-Adrenoceptor Differentially Regulate Uncoupling Protein-1 Expression [PDF]

Molecular Endocrinology, 2000
Cross-talk between insulin and the adrenergic system is important in the regulation of energy homeostasis. In cultured, differentiated mouse brown adipocytes, beta3-adrenergic stimulation induced a 4.5-fold increase in uncoupling protein-1 (UCP-1) expression, which was diminished by 25% in the presence of insulin.
J, Klein, M, Fasshauer, M, Benito, C R, Kahn   +3 more
openaire   +2 more sources

Evolution of UCP1 Transcriptional Regulatory Elements Across the Mammalian Phylogeny

Frontiers in Physiology, 2017
Uncoupling protein 1 (UCP1) permits non-shivering thermogenesis (NST) when highly expressed in brown adipose tissue (BAT) mitochondria. Exclusive to placental mammals, BAT has commonly been regarded to be advantageous for thermoregulation in hibernators,
Michael J. Gaudry, Kevin L. Campbell
doaj   +1 more source